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Mitochondria: gatekeepers of response to chemotherapy.
Sarosiek KA, Ni Chonghaile T, Letai A. Sarosiek KA, et al. Trends Cell Biol. 2013 Dec;23(12):612-9. doi: 10.1016/j.tcb.2013.08.003. Epub 2013 Sep 21. Trends Cell Biol. 2013. PMID: 24060597 Free PMC article. Review.
p53 regulates a non-apoptotic death induced by ROS.
Montero J, Dutta C, van Bodegom D, Weinstock D, Letai A. Montero J, et al. Cell Death Differ. 2013 Nov;20(11):1465-74. doi: 10.1038/cdd.2013.52. Epub 2013 May 24. Cell Death Differ. 2013. PMID: 23703322 Free PMC article.
Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy.
Ni Chonghaile T, Sarosiek KA, Vo TT, Ryan JA, Tammareddi A, Moore Vdel G, Deng J, Anderson KC, Richardson P, Tai YT, Mitsiades CS, Matulonis UA, Drapkin R, Stone R, Deangelo DJ, McConkey DJ, Sallan SE, Silverman L, Hirsch MS, Carrasco DR, Letai A. Ni Chonghaile T, et al. Science. 2011 Nov 25;334(6059):1129-33. doi: 10.1126/science.1206727. Epub 2011 Oct 27. Science. 2011. PMID: 22033517 Free PMC article.