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An NK cell line (haNK) expressing high levels of granzyme and engineered to express the high affinity CD16 allele.
Jochems C, Hodge JW, Fantini M, Fujii R, Morillon YM 2nd, Greiner JW, Padget MR, Tritsch SR, Tsang KY, Campbell KS, Klingemann H, Boissel L, Rabizadeh S, Soon-Shiong P, Schlom J. Jochems C, et al. Among authors: padget mr. Oncotarget. 2016 Dec 27;7(52):86359-86373. doi: 10.18632/oncotarget.13411. Oncotarget. 2016. PMID: 27861156 Free PMC article.
Correction to: Immunotherapy Utilizing the Combination of Natural Killer- and Antibody Dependent Cellular Cytotoxicity (ADCC)-Mediating Agents with Poly (ADP-ribose) polymerase (PARP) Inhibition.
Fenerty KE, Padget M, Wolfson B, Gameiro SR, Su Z, Lee JH, Rabizadeh S, Soon-Shiong P, Hodge JW. Fenerty KE, et al. Among authors: padget m. J Immunother Cancer. 2019 Sep 2;7(1):234. doi: 10.1186/s40425-019-0715-9. J Immunother Cancer. 2019. PMID: 31477176 Free PMC article.
Efficient ADCC killing of meningioma by avelumab and a high-affinity natural killer cell line, haNK.
Giles AJ, Hao S, Padget M, Song H, Zhang W, Lynes J, Sanchez V, Liu Y, Jung J, Cao X, Fujii R, Jensen R, Gillespie D, Schlom J, Gilbert MR, Nduom EK, Yang C, Lee JH, Soon-Shiong P, Hodge JW, Park DM. Giles AJ, et al. Among authors: padget m. JCI Insight. 2019 Oct 17;4(20):e130688. doi: 10.1172/jci.insight.130688. JCI Insight. 2019. PMID: 31536478 Free PMC article.
Overcoming hypoxia-induced functional suppression of NK cells.
Solocinski K, Padget MR, Fabian KP, Wolfson B, Cecchi F, Hembrough T, Benz SC, Rabizadeh S, Soon-Shiong P, Schlom J, Hodge JW. Solocinski K, et al. J Immunother Cancer. 2020 Apr;8(1):e000246. doi: 10.1136/jitc-2019-000246. J Immunother Cancer. 2020. PMID: 32345623 Free PMC article.
Combination of PARP Inhibitor Olaparib, and PD-L1 Inhibitor Durvalumab, in Recurrent Ovarian Cancer: a Proof-of-Concept Phase II Study.
Lampert EJ, Zimmer A, Padget M, Cimino-Mathews A, Nair JR, Liu Y, Swisher EM, Hodge JW, Nixon AB, Nichols E, Bagheri MH, Levy E, Radke MR, Lipkowitz S, Annunziata CM, Taube JM, Steinberg SM, Lee JM. Lampert EJ, et al. Among authors: padget m. Clin Cancer Res. 2020 Aug 15;26(16):4268-4279. doi: 10.1158/1078-0432.CCR-20-0056. Epub 2020 May 12. Clin Cancer Res. 2020. PMID: 32398324 Free PMC article. Clinical Trial.
43 results