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Page 1
GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis.
Kremer DM, Nelson BS, Lin L, Yarosz EL, Halbrook CJ, Kerk SA, Sajjakulnukit P, Myers A, Thurston G, Hou SW, Carpenter ES, Andren AC, Nwosu ZC, Cusmano N, Wisner S, Mbah NE, Shan M, Das NK, Magnuson B, Little AC, Savani MR, Ramos J, Gao T, Sastra SA, Palermo CF, Badgley MA, Zhang L, Asara JM, McBrayer SK, di Magliano MP, Crawford HC, Shah YM, Olive KP, Lyssiotis CA. Kremer DM, et al. Among authors: palermo cf. Nat Commun. 2021 Aug 11;12(1):4860. doi: 10.1038/s41467-021-24859-2. Nat Commun. 2021. PMID: 34381026 Free PMC article.
Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma.
Rhim AD, Oberstein PE, Thomas DH, Mirek ET, Palermo CF, Sastra SA, Dekleva EN, Saunders T, Becerra CP, Tattersall IW, Westphalen CB, Kitajewski J, Fernandez-Barrena MG, Fernandez-Zapico ME, Iacobuzio-Donahue C, Olive KP, Stanger BZ. Rhim AD, et al. Among authors: palermo cf. Cancer Cell. 2014 Jun 16;25(6):735-47. doi: 10.1016/j.ccr.2014.04.021. Epub 2014 May 22. Cancer Cell. 2014. PMID: 24856585 Free PMC article.
Preclinical pharmacologic evaluation of pralatrexate and romidepsin confirms potent synergy of the combination in a murine model of human T-cell lymphoma.
Jain S, Jirau-Serrano X, Zullo KM, Scotto L, Palermo CF, Sastra SA, Olive KP, Cremers S, Thomas T, Wei Y, Zhang Y, Bhagat G, Amengual JE, Deng C, Karan C, Realubit R, Bates SE, O'Connor OA. Jain S, et al. Among authors: palermo cf. Clin Cancer Res. 2015 May 1;21(9):2096-106. doi: 10.1158/1078-0432.CCR-14-2249. Epub 2015 Feb 12. Clin Cancer Res. 2015. PMID: 25677697
Effective Delivery of a Microtubule Polymerization Inhibitor Synergizes with Standard Regimens in Models of Pancreatic Ductal Adenocarcinoma.
Eberle-Singh JA, Sagalovskiy I, Maurer HC, Sastra SA, Palermo CF, Decker AR, Kim MJ, Sheedy J, Mollin A, Cao L, Hu J, Branstrom A, Weetall M, Olive KP. Eberle-Singh JA, et al. Among authors: palermo cf. Clin Cancer Res. 2019 Sep 15;25(18):5548-5560. doi: 10.1158/1078-0432.CCR-18-3281. Epub 2019 Jun 7. Clin Cancer Res. 2019. PMID: 31175095
Harmonic Motion Imaging of Pancreatic Tumor Stiffness Indicates Disease State and Treatment Response.
Payen T, Oberstein PE, Saharkhiz N, Palermo CF, Sastra SA, Han Y, Nabavizadeh A, Sagalovskiy IR, Orelli B, Rosario V, Desrouilleres D, Remotti H, Kluger MD, Schrope BA, Chabot JA, Iuga AC, Konofagou EE, Olive KP. Payen T, et al. Among authors: palermo cf. Clin Cancer Res. 2020 Mar 15;26(6):1297-1308. doi: 10.1158/1078-0432.CCR-18-3669. Epub 2019 Dec 12. Clin Cancer Res. 2020. PMID: 31831559 Free PMC article.
Cysteine depletion induces pancreatic tumor ferroptosis in mice.
Badgley MA, Kremer DM, Maurer HC, DelGiorno KE, Lee HJ, Purohit V, Sagalovskiy IR, Ma A, Kapilian J, Firl CEM, Decker AR, Sastra SA, Palermo CF, Andrade LR, Sajjakulnukit P, Zhang L, Tolstyka ZP, Hirschhorn T, Lamb C, Liu T, Gu W, Seeley ES, Stone E, Georgiou G, Manor U, Iuga A, Wahl GM, Stockwell BR, Lyssiotis CA, Olive KP. Badgley MA, et al. Among authors: palermo cf. Science. 2020 Apr 3;368(6486):85-89. doi: 10.1126/science.aaw9872. Science. 2020. PMID: 32241947 Free PMC article.
Noninvasive Young's modulus visualization of fibrosis progression and delineation of pancreatic ductal adenocarcinoma (PDAC) tumors using Harmonic Motion Elastography (HME) in vivo.
Nabavizadeh A, Payen T, Iuga AC, Sagalovskiy IR, Desrouilleres D, Saharkhiz N, Palermo CF, Sastra SA, Oberstein PE, Rosario V, Kluger MD, Schrope BA, Chabot JA, Olive KP, Konofagou EE. Nabavizadeh A, et al. Among authors: palermo cf. Theranostics. 2020 Mar 15;10(10):4614-4626. doi: 10.7150/thno.37965. eCollection 2020. Theranostics. 2020. PMID: 32292518 Free PMC article.
Ras-dependent activation of BMAL2 regulates hypoxic metabolism in pancreatic cancer.
Maurer HC, Curiel-Garcia A, Holmstrom S, Laise P, Palermo CF, Sastra SA, Andren A, Li Z, LeLarge T, Sagalovskiy I, Ross DR, Rosario V, Lu K, Ferraiuolo E, Spinosa N, Wong W, Shaw K, Chabot JA, Genkinger J, Hibshoosh H, Manji GA, Iuga A, Schmid RM, Badgley MA, Johnson K, Califano A, Lyssiotis C, Olive KP. Maurer HC, et al. Among authors: palermo cf. bioRxiv [Preprint]. 2023 Mar 21:2023.03.19.533333. doi: 10.1101/2023.03.19.533333. bioRxiv. 2023. PMID: 36993718 Free PMC article. Preprint.
An NFATc1/SMAD3/cJUN Complex Restricted to SMAD4-Deficient Pancreatic Cancer Guides Rational Therapies.
Hasselluhn MC, Schlösser D, Versemann L, Schmidt GE, Ulisse M, Oschwald J, Zhang Z, Hamdan F, Xiao H, Kopp W, Spitalieri J, Kellner C, Schneider C, Reutlinger K, Nagarajan S, Steuber B, Sastra SA, Palermo CF, Appelhans J, Bohnenberger H, Todorovic J, Kostyuchek I, Ströbel P, Bockelmann A, König A, Ammer-Herrmenau C, Schmidleitner L, Kaulfuß S, Wollnik B, Hahn SA, Neesse A, Singh SK, Bastians H, Reichert M, Sax U, Olive KP, Johnsen SA, Schneider G, Ellenrieder V, Hessmann E. Hasselluhn MC, et al. Among authors: palermo cf. Gastroenterology. 2024 Feb;166(2):298-312.e14. doi: 10.1053/j.gastro.2023.10.026. Epub 2023 Oct 31. Gastroenterology. 2024. PMID: 37913894
15 results