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Retinol Saturase: More than the Name Suggests.
Weber P, Flores RE, Kiefer MF, Schupp M. Weber P, et al. Trends Pharmacol Sci. 2020 Jun;41(6):418-427. doi: 10.1016/j.tips.2020.03.007. Epub 2020 Apr 25. Trends Pharmacol Sci. 2020. PMID: 32345479 Review.
The glucose-sensing transcription factor ChREBP is targeted by proline hydroxylation.
Heidenreich S, Weber P, Stephanowitz H, Petricek KM, Schütte T, Oster M, Salo AM, Knauer M, Goehring I, Yang N, Witte N, Schumann A, Sommerfeld M, Muenzner M, Myllyharju J, Krause E, Schupp M. Heidenreich S, et al. Among authors: weber p. J Biol Chem. 2020 Dec 11;295(50):17158-17168. doi: 10.1074/jbc.RA120.014402. Epub 2020 Oct 6. J Biol Chem. 2020. PMID: 33023907 Free PMC article.
Liver-secreted RBP4 does not impair glucose homeostasis in mice.
Fedders R, Muenzner M, Weber P, Sommerfeld M, Knauer M, Kedziora S, Kast N, Heidenreich S, Raila J, Weger S, Henze A, Schupp M. Fedders R, et al. Among authors: weber p. J Biol Chem. 2018 Sep 28;293(39):15269-15276. doi: 10.1074/jbc.RA118.004294. Epub 2018 Aug 20. J Biol Chem. 2018. PMID: 30126844 Free PMC article.
Retinol saturase coordinates liver metabolism by regulating ChREBP activity.
Heidenreich S, Witte N, Weber P, Goehring I, Tolkachov A, von Loeffelholz C, Döcke S, Bauer M, Stockmann M, Pfeiffer AFH, Birkenfeld AL, Pietzke M, Kempa S, Muenzner M, Schupp M. Heidenreich S, et al. Among authors: weber p. Nat Commun. 2017 Aug 30;8(1):384. doi: 10.1038/s41467-017-00430-w. Nat Commun. 2017. PMID: 28855500 Free PMC article.