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The Rac-GEF Tiam1 controls integrin-dependent neutrophil responses.
Hornigold K, Baker MJ, Machin PA, Chetwynd SA, Johnsson AK, Pantarelli C, Islam P, Stammers M, Crossland L, Oxley D, Okkenhaug H, Walker S, Walker R, Segonds-Pichon A, Fukui Y, Malliri A, Welch HCE. Hornigold K, et al. Among authors: pantarelli c. Front Immunol. 2023 Nov 21;14:1223653. doi: 10.3389/fimmu.2023.1223653. eCollection 2023. Front Immunol. 2023. PMID: 38077328 Free PMC article.
Dock2 generates characteristic spatiotemporal patterns of Rac activity to regulate neutrophil polarisation, migration and phagocytosis.
Machin PA, Johnsson AE, Massey EJ, Pantarelli C, Chetwynd SA, Chu JY, Okkenhaug H, Segonds-Pichon A, Walker S, Malliri A, Fukui Y, Welch HCE. Machin PA, et al. Among authors: pantarelli c. Front Immunol. 2023 Jun 13;14:1180886. doi: 10.3389/fimmu.2023.1180886. eCollection 2023. Front Immunol. 2023. PMID: 37383235 Free PMC article.
Memory of stochastic single-cell apoptotic signaling promotes chemoresistance in neuroblastoma.
Hastings JF, Latham SL, Kamili A, Wheatley MS, Han JZR, Wong-Erasmus M, Phimmachanh M, Nobis M, Pantarelli C, Cadell AL, O'Donnell YEI, Leong KH, Lynn S, Geng FS, Cui L, Yan S, Achinger-Kawecka J, Stirzaker C, Norris MD, Haber M, Trahair TN, Speleman F, De Preter K, Cowley MJ, Bogdanovic O, Timpson P, Cox TR, Kolch W, Fletcher JI, Fey D, Croucher DR. Hastings JF, et al. Among authors: pantarelli c. Sci Adv. 2023 Mar 3;9(9):eabp8314. doi: 10.1126/sciadv.abp8314. Epub 2023 Mar 3. Sci Adv. 2023. PMID: 36867694 Free PMC article.
The GPCR adaptor protein norbin suppresses the neutrophil-mediated immunity of mice to pneumococcal infection.
Pantarelli C, Pan D, Chetwynd S, Stark AK, Hornigold K, Machin P, Crossland L, Cleary SJ, Baker MJ, Hampson E, Mandel A, Segonds-Pichon A, Walker R, van 't Veer C, Riffo-Vasquez Y, Okkenhaug K, Pitchford S, Welch HCE. Pantarelli C, et al. Blood Adv. 2021 Aug 24;5(16):3076-3091. doi: 10.1182/bloodadvances.2020002782. Blood Adv. 2021. PMID: 34402884 Free PMC article.