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The serine hydroxymethyltransferase-2 (SHMT2) initiates lymphoma development through epigenetic tumor suppressor silencing.
Parsa S, Ortega-Molina A, Ying HY, Jiang M, Teater M, Wang J, Zhao C, Reznik E, Pasion JP, Kuo D, Mohan P, Wang S, Camarillo JM, Thomas PM, Jain N, Garcia-Bermudez J, Cho BK, Tam W, Kelleher NL, Socci N, Dogan A, De Stanchina E, Ciriello G, Green MR, Li S, Birsoy K, Melnick AM, Wendel HG. Parsa S, et al. Among authors: pasion jp. Nat Cancer. 2020;1:653-664. doi: 10.1038/s43018-020-0080-0. Epub 2020 Jun 22. Nat Cancer. 2020. PMID: 33569544 Free PMC article.
Genetic and epigenetic inactivation of SESTRIN1 controls mTORC1 and response to EZH2 inhibition in follicular lymphoma.
Oricchio E, Katanayeva N, Donaldson MC, Sungalee S, Pasion JP, Béguelin W, Battistello E, Sanghvi VR, Jiang M, Jiang Y, Teater M, Parmigiani A, Budanov AV, Chan FC, Shah SP, Kridel R, Melnick AM, Ciriello G, Wendel HG. Oricchio E, et al. Among authors: pasion jp. Sci Transl Med. 2017 Jun 28;9(396):eaak9969. doi: 10.1126/scitranslmed.aak9969. Sci Transl Med. 2017. PMID: 28659443 Free PMC article.