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Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia.
Yankova E, Blackaby W, Albertella M, Rak J, De Braekeleer E, Tsagkogeorga G, Pilka ES, Aspris D, Leggate D, Hendrick AG, Webster NA, Andrews B, Fosbeary R, Guest P, Irigoyen N, Eleftheriou M, Gozdecka M, Dias JML, Bannister AJ, Vick B, Jeremias I, Vassiliou GS, Rausch O, Tzelepis K, Kouzarides T. Yankova E, et al. Among authors: guest p. Nature. 2021 May;593(7860):597-601. doi: 10.1038/s41586-021-03536-w. Epub 2021 Apr 26. Nature. 2021. PMID: 33902106 Free PMC article.
Design, synthesis and in vitro evaluation of benzothiazole-based ureas as potential ABAD/17β-HSD10 modulators for Alzheimer's disease treatment.
Hroch L, Benek O, Guest P, Aitken L, Soukup O, Janockova J, Musil K, Dohnal V, Dolezal R, Kuca K, Smith TK, Gunn-Moore F, Musilek K. Hroch L, et al. Among authors: guest p. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3675-8. doi: 10.1016/j.bmcl.2016.05.087. Epub 2016 May 30. Bioorg Med Chem Lett. 2016. PMID: 27287370