Pattenden LK - Search Results

1

Synthesis, stability, antiviral activity, and protease-bound structures of substrate-mimicking constrained macrocyclic inhibitors of HIV-1 protease.

Tyndall JD, Reid RC, Tyssen DP, Jardine DK, Todd B, Passmore M, March DR, Pattenden LK, Bergman DA, Alewood D, Hu SH, Alewood PF, Birch CJ, Martin JL, Fairlie DP. Tyndall JD, et al. Among authors: pattenden lk. J Med Chem. 2000 Sep 21;43(19):3495-504. doi: 10.1021/jm000013n. J Med Chem. 2000. PMID: 11000004

2

Beta-strand mimicking macrocyclic amino acids: templates for protease inhibitors with antiviral activity.

Glenn MP, Pattenden LK, Reid RC, Tyssen DP, Tyndall JD, Birch CJ, Fairlie DP. Glenn MP, et al. Among authors: pattenden lk. J Med Chem. 2002 Jan 17;45(2):371-81. doi: 10.1021/jm010414i. J Med Chem. 2002. PMID: 11784141

3

Countering cooperative effects in protease inhibitors using constrained beta-strand-mimicking templates in focused combinatorial libraries.

Reid RC, Pattenden LK, Tyndall JD, Martin JL, Walsh T, Fairlie DP. Reid RC, et al. Among authors: pattenden lk. J Med Chem. 2004 Mar 25;47(7):1641-51. doi: 10.1021/jm030337m. J Med Chem. 2004. PMID: 15027855

4

Crystal structures of highly constrained substrate and hydrolysis products bound to HIV-1 protease. Implications for the catalytic mechanism.

Tyndall JD, Pattenden LK, Reid RC, Hu SH, Alewood D, Alewood PF, Walsh T, Fairlie DP, Martin JL. Tyndall JD, et al. Among authors: pattenden lk. Biochemistry. 2008 Mar 25;47(12):3736-44. doi: 10.1021/bi7023157. Epub 2008 Mar 1. Biochemistry. 2008. PMID: 18311928

5

The toxicity of prion protein fragment PrP(106-126) is not mediated by membrane permeabilization as shown by a M112W substitution.

Henriques ST, Pattenden LK, Aguilar MI, Castanho MA. Henriques ST, et al. Among authors: pattenden lk. Biochemistry. 2009 May 19;48(19):4198-208. doi: 10.1021/bi900009d. Biochemistry. 2009. PMID: 19301918

6

Role of helix 8 in G protein-coupled receptors based on structure-function studies on the type 1 angiotensin receptor.

Huynh J, Thomas WG, Aguilar MI, Pattenden LK. Huynh J, et al. Among authors: pattenden lk. Mol Cell Endocrinol. 2009 Apr 29;302(2):118-27. doi: 10.1016/j.mce.2009.01.002. Mol Cell Endocrinol. 2009. PMID: 19418628 Review.

7

Helix 8 of the angiotensin- II type 1A receptor interacts with phosphatidylinositol phosphates and modulates membrane insertion.

Hirst DJ, Lee TH, Pattenden LK, Thomas WG, Aguilar MI. Hirst DJ, et al. Among authors: pattenden lk. Sci Rep. 2015 Jun 30;5:9972. doi: 10.1038/srep09972. Sci Rep. 2015. PMID: 26126083 Free PMC article.

8

Towards the preparative and large-scale precision manufacture of virus-like particles.

Pattenden LK, Middelberg AP, Niebert M, Lipin DI. Pattenden LK, et al. Trends Biotechnol. 2005 Oct;23(10):523-9. doi: 10.1016/j.tibtech.2005.07.011. Trends Biotechnol. 2005. PMID: 16084615 Review.

9

Interactions of HIV-1 antibodies 2F5 and 4E10 with a gp41 epitope prebound to host and viral membrane model systems.

Veiga AS, Pattenden LK, Fletcher JM, Castanho MA, Aguilar MI. Veiga AS, et al. Among authors: pattenden lk. Chembiochem. 2009 Apr 17;10(6):1032-44. doi: 10.1002/cbic.200800609. Chembiochem. 2009. PMID: 19283693

10

Ligand-supported purification of the urotensin-II receptor.

Du AT, Onan D, Dinh DT, Lew MJ, Ziogas J, Aguilar MI, Pattenden LK, Thomas WG. Du AT, et al. Among authors: pattenden lk. Mol Pharmacol. 2010 Oct;78(4):639-47. doi: 10.1124/mol.110.065151. Epub 2010 Jul 20. Mol Pharmacol. 2010. PMID: 20647393

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