Patterson A - Search Results

1

2,4-Diarylamino-pyrimidines as kinase inhibitors co-targeting IGF1R and EGFR(L⁸⁵⁸R/T⁷⁹⁰M).

Chan S, Han K, Qu R, Tong L, Li Y, Zhang Z, Cheng H, Lu X, Patterson A, Smaill J, Ren X, Ding J, Xie H, Ding K. Chan S, et al. Among authors: patterson a. Bioorg Med Chem Lett. 2015 Oct 1;25(19):4277-81. doi: 10.1016/j.bmcl.2015.07.089. Epub 2015 Jul 30. Bioorg Med Chem Lett. 2015. PMID: 26259806

2

Structure-activity relationships of 1,2,4-benzotriazine 1,4-dioxides as hypoxia-selective analogues of tirapazamine.

Hay MP, Gamage SA, Kovacs MS, Pruijn FB, Anderson RF, Patterson AV, Wilson WR, Brown JM, Denny WA. Hay MP, et al. Among authors: patterson av. J Med Chem. 2003 Jan 2;46(1):169-82. doi: 10.1021/jm020367+. J Med Chem. 2003. PMID: 12502371

3

DNA-targeted 1,2,4-benzotriazine 1,4-dioxides: potent analogues of the hypoxia-selective cytotoxin tirapazamine.

Hay MP, Pruijn FB, Gamage SA, Liyanage HD, Kovacs MS, Patterson AV, Wilson WR, Brown JM, Denny WA. Hay MP, et al. Among authors: patterson av. J Med Chem. 2004 Jan 15;47(2):475-88. doi: 10.1021/jm030399c. J Med Chem. 2004. PMID: 14711317

4

Synthesis and structure-activity relationships for 2,4-dinitrobenzamide-5-mustards as prodrugs for the Escherichia coli nfsB nitroreductase in gene therapy.

Atwell GJ, Yang S, Pruijn FB, Pullen SM, Hogg A, Patterson AV, Wilson WR, Denny WA. Atwell GJ, et al. Among authors: patterson av. J Med Chem. 2007 Mar 22;50(6):1197-212. doi: 10.1021/jm061062o. Epub 2007 Feb 28. J Med Chem. 2007. PMID: 17326614

5

The nitroreductase prodrug SN 28343 enhances the potency of systemically administered armed oncolytic adenovirus ONYX-411(NTR).

Singleton DC, Li D, Bai SY, Syddall SP, Smaill JB, Shen Y, Denny WA, Wilson WR, Patterson AV. Singleton DC, et al. Among authors: patterson av. Cancer Gene Ther. 2007 Dec;14(12):953-67. doi: 10.1038/sj.cgt.7701088. Epub 2007 Nov 2. Cancer Gene Ther. 2007. PMID: 17975564

6

Discovery and evaluation of Escherichia coli nitroreductases that activate the anti-cancer prodrug CB1954.

Prosser GA, Copp JN, Syddall SP, Williams EM, Smaill JB, Wilson WR, Patterson AV, Ackerley DF. Prosser GA, et al. Among authors: patterson av. Biochem Pharmacol. 2010 Mar 1;79(5):678-87. doi: 10.1016/j.bcp.2009.10.008. Epub 2009 Oct 21. Biochem Pharmacol. 2010. PMID: 19852945

7

Targeted mutagenesis of the Vibrio fischeri flavin reductase FRase I to improve activation of the anticancer prodrug CB1954.

Swe PM, Copp JN, Green LK, Guise CP, Mowday AM, Smaill JB, Patterson AV, Ackerley DF. Swe PM, et al. Among authors: patterson av. Biochem Pharmacol. 2012 Sep 15;84(6):775-83. doi: 10.1016/j.bcp.2012.07.002. Epub 2012 Jul 14. Biochem Pharmacol. 2012. PMID: 22796568

8

Bioreductive prodrugs as cancer therapeutics: targeting tumor hypoxia.

Guise CP, Mowday AM, Ashoorzadeh A, Yuan R, Lin WH, Wu DH, Smaill JB, Patterson AV, Ding K. Guise CP, et al. Among authors: patterson av. Chin J Cancer. 2014 Feb;33(2):80-6. doi: 10.5732/cjc.012.10285. Epub 2013 Jul 12. Chin J Cancer. 2014. PMID: 23845143 Free PMC article. Review.

9

Zinc finger nuclease knock-out of NADPH:cytochrome P450 oxidoreductase (POR) in human tumor cell lines demonstrates that hypoxia-activated prodrugs differ in POR dependence.

Su J, Gu Y, Pruijn FB, Smaill JB, Patterson AV, Guise CP, Wilson WR. Su J, et al. J Biol Chem. 2013 Dec 27;288(52):37138-53. doi: 10.1074/jbc.M113.505222. Epub 2013 Nov 6. J Biol Chem. 2013. PMID: 24196959 Free PMC article.

10

The Flavin Reductase MsuE Is a Novel Nitroreductase that Can Efficiently Activate Two Promising Next-Generation Prodrugs for Gene-Directed Enzyme Prodrug Therapy.

Green LK, Storey MA, Williams EM, Patterson AV, Smaill JB, Copp JN, Ackerley DF. Green LK, et al. Among authors: patterson av. Cancers (Basel). 2013 Aug 8;5(3):985-97. doi: 10.3390/cancers5030985. Cancers (Basel). 2013. PMID: 24202330 Free PMC article.

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