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DPP-4 is expressed in human pancreatic beta cells and its direct inhibition improves beta cell function and survival in type 2 diabetes.
Bugliani M, Syed F, Paula FMM, Omar BA, Suleiman M, Mossuto S, Grano F, Cardarelli F, Boggi U, Vistoli F, Filipponi F, De Simone P, Marselli L, De Tata V, Ahren B, Eizirik DL, Marchetti P. Bugliani M, et al. Among authors: paula fmm. Mol Cell Endocrinol. 2018 Sep 15;473:186-193. doi: 10.1016/j.mce.2018.01.019. Epub 2018 Feb 1. Mol Cell Endocrinol. 2018. PMID: 29409957
Offspring from trained male mice inherit improved muscle mitochondrial function through PPAR co-repressor modulation.
Freitas-Dias R, Lima TI, Costa-Junior JM, Gonçalves LM, Araujo HN, Paula FMM, Santos GJ, Branco RCS, Ou K, Kaestner KH, Silveira LR, Oliveira CAM, Boschero AC, Zoppi CC, Carneiro EM. Freitas-Dias R, et al. Among authors: paula fmm. Life Sci. 2022 Feb 15;291:120239. doi: 10.1016/j.lfs.2021.120239. Epub 2021 Dec 21. Life Sci. 2022. PMID: 34942163
PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 induction.
Colli ML, Hill JLE, Marroquí L, Chaffey J, Dos Santos RS, Leete P, Coomans de Brachène A, Paula FMM, Op de Beeck A, Castela A, Marselli L, Krogvold L, Dahl-Jorgensen K, Marchetti P, Morgan NG, Richardson SJ, Eizirik DL. Colli ML, et al. Among authors: paula fmm. EBioMedicine. 2018 Oct;36:367-375. doi: 10.1016/j.ebiom.2018.09.040. Epub 2018 Sep 27. EBioMedicine. 2018. PMID: 30269996 Free PMC article.
Hyperinsulinemia caused by dexamethasone treatment is associated with reduced insulin clearance and lower hepatic activity of insulin-degrading enzyme.
Protzek AO, Rezende LF, Costa-Júnior JM, Ferreira SM, Cappelli AP, de Paula FM, de Souza JC, Kurauti MA, Carneiro EM, Rafacho A, Boschero AC. Protzek AO, et al. J Steroid Biochem Mol Biol. 2016 Jan;155(Pt A):1-8. doi: 10.1016/j.jsbmb.2015.09.020. Epub 2015 Sep 16. J Steroid Biochem Mol Biol. 2016. PMID: 26386462
12 results