Pearson RB - Search Results

1

The inositol polyphosphate 5-phosphatase, PIPP, Is a novel regulator of phosphoinositide 3-kinase-dependent neurite elongation.

Ooms LM, Fedele CG, Astle MV, Ivetac I, Cheung V, Pearson RB, Layton MJ, Forrai A, Nandurkar HH, Mitchell CA. Ooms LM, et al. Among authors: pearson rb. Mol Biol Cell. 2006 Feb;17(2):607-22. doi: 10.1091/mbc.e05-05-0469. Epub 2005 Nov 9. Mol Biol Cell. 2006. PMID: 16280363 Free PMC article.

2

UBF levels determine the number of active ribosomal RNA genes in mammals.

Sanij E, Poortinga G, Sharkey K, Hung S, Holloway TP, Quin J, Robb E, Wong LH, Thomas WG, Stefanovsky V, Moss T, Rothblum L, Hannan KM, McArthur GA, Pearson RB, Hannan RD. Sanij E, et al. Among authors: pearson rb. J Cell Biol. 2008 Dec 29;183(7):1259-74. doi: 10.1083/jcb.200805146. Epub 2008 Dec 22. J Cell Biol. 2008. PMID: 19103806 Free PMC article.

3

AKT promotes rRNA synthesis and cooperates with c-MYC to stimulate ribosome biogenesis in cancer.

Chan JC, Hannan KM, Riddell K, Ng PY, Peck A, Lee RS, Hung S, Astle MV, Bywater M, Wall M, Poortinga G, Jastrzebski K, Sheppard KE, Hemmings BA, Hall MN, Johnstone RW, McArthur GA, Hannan RD, Pearson RB. Chan JC, et al. Among authors: pearson rb. Sci Signal. 2011 Aug 30;4(188):ra56. doi: 10.1126/scisignal.2001754. Sci Signal. 2011. PMID: 21878679

4

AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy.

Astle MV, Hannan KM, Ng PY, Lee RS, George AJ, Hsu AK, Haupt Y, Hannan RD, Pearson RB. Astle MV, et al. Among authors: pearson rb. Oncogene. 2012 Apr 12;31(15):1949-62. doi: 10.1038/onc.2011.394. Epub 2011 Sep 12. Oncogene. 2012. PMID: 21909130 Free PMC article.

5

An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in mice.

Kinross KM, Montgomery KG, Kleinschmidt M, Waring P, Ivetac I, Tikoo A, Saad M, Hare L, Roh V, Mantamadiotis T, Sheppard KE, Ryland GL, Campbell IG, Gorringe KL, Christensen JG, Cullinane C, Hicks RJ, Pearson RB, Johnstone RW, McArthur GA, Phillips WA. Kinross KM, et al. Among authors: pearson rb. J Clin Invest. 2012 Feb;122(2):553-7. doi: 10.1172/JCI59309. Epub 2012 Jan 3. J Clin Invest. 2012. PMID: 22214849 Free PMC article.

6

The mTORC1 inhibitor everolimus prevents and treats Eμ-Myc lymphoma by restoring oncogene-induced senescence.

Wall M, Poortinga G, Stanley KL, Lindemann RK, Bots M, Chan CJ, Bywater MJ, Kinross KM, Astle MV, Waldeck K, Hannan KM, Shortt J, Smyth MJ, Lowe SW, Hannan RD, Pearson RB, Johnstone RW, McArthur GA. Wall M, et al. Among authors: pearson rb. Cancer Discov. 2013 Jan;3(1):82-95. doi: 10.1158/2159-8290.CD-12-0404. Epub 2012 Dec 14. Cancer Discov. 2013. PMID: 23242809 Free PMC article.

7

Autophosphorylation of serine 608 in the p85 regulatory subunit of wild type or cancer-associated mutants of phosphoinositide 3-kinase does not affect its lipid kinase activity.

Layton MJ, Saad M, Church NL, Pearson RB, Mitchell CA, Phillips WA. Layton MJ, et al. Among authors: pearson rb. BMC Biochem. 2012 Dec 27;13:30. doi: 10.1186/1471-2091-13-30. BMC Biochem. 2012. PMID: 23270540 Free PMC article.

8

A specific role for AKT3 in the genesis of ovarian cancer through modulation of G(2)-M phase transition.

Cristiano BE, Chan JC, Hannan KM, Lundie NA, Marmy-Conus NJ, Campbell IG, Phillips WA, Robbie M, Hannan RD, Pearson RB. Cristiano BE, et al. Among authors: pearson rb. Cancer Res. 2006 Dec 15;66(24):11718-25. doi: 10.1158/0008-5472.CAN-06-1968. Cancer Res. 2006. PMID: 17178867

9

Phosphorylation regulates copper-responsive trafficking of the Menkes copper transporting P-type ATPase.

Veldhuis NA, Valova VA, Gaeth AP, Palstra N, Hannan KM, Michell BJ, Kelly LE, Jennings I, Kemp BE, Pearson RB, Robinson PJ, Camakaris J. Veldhuis NA, et al. Among authors: pearson rb. Int J Biochem Cell Biol. 2009 Dec;41(12):2403-12. doi: 10.1016/j.biocel.2009.06.008. Epub 2009 Jul 2. Int J Biochem Cell Biol. 2009. PMID: 19576997

10

Targeting of the tumor suppressor GRHL3 by a miR-21-dependent proto-oncogenic network results in PTEN loss and tumorigenesis.

Darido C, Georgy SR, Wilanowski T, Dworkin S, Auden A, Zhao Q, Rank G, Srivastava S, Finlay MJ, Papenfuss AT, Pandolfi PP, Pearson RB, Jane SM. Darido C, et al. Among authors: pearson rb. Cancer Cell. 2011 Nov 15;20(5):635-48. doi: 10.1016/j.ccr.2011.10.014. Cancer Cell. 2011. PMID: 22094257 Free article.

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