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Resminostat plus sorafenib as second-line therapy of advanced hepatocellular carcinoma - The SHELTER study.
Bitzer M, Horger M, Giannini EG, Ganten TM, Wörns MA, Siveke JT, Dollinger MM, Gerken G, Scheulen ME, Wege H, Zagonel V, Cillo U, Trevisani F, Santoro A, Montesarchio V, Malek NP, Holzapfel J, Herz T, Ammendola AS, Pegoraro S, Hauns B, Mais A, Lauer UM, Henning SW, Hentsch B. Bitzer M, et al. Among authors: pegoraro s. J Hepatol. 2016 Aug;65(2):280-8. doi: 10.1016/j.jhep.2016.02.043. Epub 2016 Mar 4. J Hepatol. 2016. PMID: 26952006 Clinical Trial.
Substituted 2-arylbenzothiazoles as kinase inhibitors: hit-to-lead optimization.
Tasler S, Müller O, Wieber T, Herz T, Pegoraro S, Saeb W, Lang M, Krauss R, Totzke F, Zirrgiebel U, Ehlert JE, Kubbutat MH, Schächtele C. Tasler S, et al. Among authors: pegoraro s. Bioorg Med Chem. 2009 Sep 15;17(18):6728-37. doi: 10.1016/j.bmc.2009.07.047. Epub 2009 Jul 25. Bioorg Med Chem. 2009. PMID: 19692247
Non-competitive inhibitors of metabotropic glutamate receptor 5 (mGluR5).
Tasler S, Kraus J, Pegoraro S, Aschenbrenner A, Poggesi E, Testa R, Motta G, Leonardi A. Tasler S, et al. Among authors: pegoraro s. Bioorg Med Chem Lett. 2005 Jun 2;15(11):2876-80. doi: 10.1016/j.bmcl.2005.03.089. Bioorg Med Chem Lett. 2005. PMID: 15878659
Inhibitors of potassium channels KV1.3 and IK-1 as immunosuppressants.
Pegoraro S, Lang M, Dreker T, Kraus J, Hamm S, Meere C, Feurle J, Tasler S, Prütting S, Kuras Z, Visan V, Grissmer S. Pegoraro S, et al. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2299-304. doi: 10.1016/j.bmcl.2009.02.077. Epub 2009 Feb 25. Bioorg Med Chem Lett. 2009. PMID: 19282171
SC83288 is a clinical development candidate for the treatment of severe malaria.
Pegoraro S, Duffey M, Otto TD, Wang Y, Rösemann R, Baumgartner R, Fehler SK, Lucantoni L, Avery VM, Moreno-Sabater A, Mazier D, Vial HJ, Strobl S, Sanchez CP, Lanzer M. Pegoraro S, et al. Nat Commun. 2017 Jan 31;8:14193. doi: 10.1038/ncomms14193. Nat Commun. 2017. PMID: 28139658 Free PMC article.
81 results