Pehar M - Search Results

1

P44, the 'longevity-assurance' isoform of P53, regulates tau phosphorylation and is activated in an age-dependent fashion.

Pehar M, Ko MH, Li M, Scrable H, Puglielli L. Pehar M, et al. Aging Cell. 2014 Jun;13(3):449-56. doi: 10.1111/acel.12192. Epub 2014 Feb 25. Aging Cell. 2014. PMID: 24341977 Free PMC article.

2

Altered longevity-assurance activity of p53:p44 in the mouse causes memory loss, neurodegeneration and premature death.

Pehar M, O'Riordan KJ, Burns-Cusato M, Andrzejewski ME, del Alcazar CG, Burger C, Scrable H, Puglielli L. Pehar M, et al. Aging Cell. 2010 Apr;9(2):174-90. doi: 10.1111/j.1474-9726.2010.00547.x. Aging Cell. 2010. PMID: 20409077 Free PMC article.

3

AT-1 is the ER membrane acetyl-CoA transporter and is essential for cell viability.

Jonas MC, Pehar M, Puglielli L. Jonas MC, et al. Among authors: pehar m. J Cell Sci. 2010 Oct 1;123(Pt 19):3378-88. doi: 10.1242/jcs.068841. Epub 2010 Sep 7. J Cell Sci. 2010. PMID: 20826464 Free PMC article.

4

Biochemical inhibition of the acetyltransferases ATase1 and ATase2 reduces β-secretase (BACE1) levels and Aβ generation.

Ding Y, Ko MH, Pehar M, Kotch F, Peters NR, Luo Y, Salamat SM, Puglielli L. Ding Y, et al. Among authors: pehar m. J Biol Chem. 2012 Mar 9;287(11):8424-33. doi: 10.1074/jbc.M111.310136. Epub 2012 Jan 20. J Biol Chem. 2012. PMID: 22267734 Free PMC article.

5

Proteomic assessment shows that many endoplasmic reticulum (ER)-resident proteins are targeted by N(epsilon)-lysine acetylation in the lumen of the organelle and predicts broad biological impact.

Pehar M, Lehnus M, Karst A, Puglielli L. Pehar M, et al. J Biol Chem. 2012 Jun 29;287(27):22436-40. doi: 10.1074/jbc.C112.362871. Epub 2012 May 24. J Biol Chem. 2012. PMID: 22628546 Free PMC article.

6

SLC33A1/AT-1 protein regulates the induction of autophagy downstream of IRE1/XBP1 pathway.

Pehar M, Jonas MC, Hare TM, Puglielli L. Pehar M, et al. J Biol Chem. 2012 Aug 24;287(35):29921-30. doi: 10.1074/jbc.M112.363911. Epub 2012 Jul 11. J Biol Chem. 2012. PMID: 22787145 Free PMC article.

7

Lysine acetylation in the lumen of the ER: a novel and essential function under the control of the UPR.

Pehar M, Puglielli L. Pehar M, et al. Biochim Biophys Acta. 2013 Mar;1833(3):686-97. doi: 10.1016/j.bbamcr.2012.12.004. Epub 2012 Dec 13. Biochim Biophys Acta. 2013. PMID: 23247107 Free PMC article. Review.

8

Calorie restriction attenuates astrogliosis but not amyloid plaque load in aged rhesus macaques: a preliminary quantitative imaging study.

Sridharan A, Pehar M, Salamat MS, Pugh TD, Bendlin BB, Willette AA, Anderson RM, Kemnitz JW, Colman RJ, Weindruch RH, Puglielli L, Johnson SC. Sridharan A, et al. Among authors: pehar m. Brain Res. 2013 May 1;1508:1-8. doi: 10.1016/j.brainres.2013.02.046. Epub 2013 Mar 7. Brain Res. 2013. PMID: 23473840 Free PMC article.

9

Post-translational regulation of CD133 by ATase1/ATase2-mediated lysine acetylation.

Mak AB, Pehar M, Nixon AM, Williams RA, Uetrecht AC, Puglielli L, Moffat J. Mak AB, et al. Among authors: pehar m. J Mol Biol. 2014 May 29;426(11):2175-82. doi: 10.1016/j.jmb.2014.02.012. Epub 2014 Feb 17. J Mol Biol. 2014. PMID: 24556617 Free PMC article.

10

Deficient import of acetyl-CoA into the ER lumen causes neurodegeneration and propensity to infections, inflammation, and cancer.

Peng Y, Li M, Clarkson BD, Pehar M, Lao PJ, Hillmer AT, Barnhart TE, Christian BT, Mitchell HA, Bendlin BB, Sandor M, Puglielli L. Peng Y, et al. Among authors: pehar m. J Neurosci. 2014 May 14;34(20):6772-89. doi: 10.1523/JNEUROSCI.0077-14.2014. J Neurosci. 2014. PMID: 24828632 Free PMC article.

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