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Mu opioid receptors on hippocampal GABAergic interneurons are critical for the antidepressant effects of tianeptine.
Neuropsychopharmacology. 2022 Jun;47(7):1387-1397. doi: 10.1038/s41386-021-01192-2. Epub 2021 Sep 30.
Neuropsychopharmacology. 2022.
PMID: 34593976
Free PMC article.
Tianeptine, but not fluoxetine, decreases avoidant behavior in a mouse model of early developmental exposure to fluoxetine.
Pekarskaya EA, Holt ES, Gingrich JA, Ansorge MS, Javitch JA, Canetta SE.
Pekarskaya EA, et al.
Sci Rep. 2021 Nov 24;11(1):22852. doi: 10.1038/s41598-021-02074-9.
Sci Rep. 2021.
PMID: 34819526
Free PMC article.
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7-Hydroxymitragynine Is an Active Metabolite of Mitragynine and a Key Mediator of Its Analgesic Effects.
Kruegel AC, Uprety R, Grinnell SG, Langreck C, Pekarskaya EA, Le Rouzic V, Ansonoff M, Gassaway MM, Pintar JE, Pasternak GW, Javitch JA, Majumdar S, Sames D.
Kruegel AC, et al. Among authors: pekarskaya ea.
ACS Cent Sci. 2019 Jun 26;5(6):992-1001. doi: 10.1021/acscentsci.9b00141. Epub 2019 May 29.
ACS Cent Sci. 2019.
PMID: 31263758
Free PMC article.
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Tianeptine promotes lasting antiallodynic effects in a mouse model of neuropathic pain.
Serafini RA, Estill M, Pekarskaya EA, Sakloth F, Shen L, Javitch JA, Zachariou V.
Serafini RA, et al. Among authors: pekarskaya ea.
Neuropsychopharmacology. 2023 Oct;48(11):1680-1689. doi: 10.1038/s41386-023-01645-w. Epub 2023 Jul 20.
Neuropsychopharmacology. 2023.
PMID: 37474762
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