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SMARCB1 loss induces druggable cyclin D1 deficiency via upregulation of MIR17HG in atypical teratoid rhabdoid tumors.
Xue Y, Zhu X, Meehan B, Venneti S, Martinez D, Morin G, Maïga RI, Chen H, Papadakis AI, Johnson RM, O'Sullivan MJ, Erdreich-Epstein A, Gotlieb WH, Park M, Judkins AR, Pelletier J, Foulkes WD, Rak J, Huang S. Xue Y, et al. Among authors: pelletier j. J Pathol. 2020 Sep;252(1):77-87. doi: 10.1002/path.5493. Epub 2020 Aug 1. J Pathol. 2020. PMID: 32558936 Free article.
Adapting CRISPR/Cas9 for functional genomics screens.
Malina A, Katigbak A, Cencic R, Maïga RI, Robert F, Miura H, Pelletier J. Malina A, et al. Among authors: pelletier j. Methods Enzymol. 2014;546:193-213. doi: 10.1016/B978-0-12-801185-0.00010-6. Methods Enzymol. 2014. PMID: 25398342
Developing anti-neoplastic biotherapeutics against eIF4F.
Steinberger J, Chu J, Maïga RI, Sleiman K, Pelletier J. Steinberger J, et al. Among authors: pelletier j. Cell Mol Life Sci. 2017 May;74(9):1681-1692. doi: 10.1007/s00018-016-2430-8. Epub 2016 Dec 21. Cell Mol Life Sci. 2017. PMID: 28004147 Review.
CDK4/6 inhibitors target SMARCA4-determined cyclin D1 deficiency in hypercalcemic small cell carcinoma of the ovary.
Xue Y, Meehan B, Macdonald E, Venneti S, Wang XQD, Witkowski L, Jelinic P, Kong T, Martinez D, Morin G, Firlit M, Abedini A, Johnson RM, Cencic R, Patibandla J, Chen H, Papadakis AI, Auguste A, de Rink I, Kerkhoven RM, Bertos N, Gotlieb WH, Clarke BA, Leary A, Witcher M, Guiot MC, Pelletier J, Dostie J, Park M, Judkins AR, Hass R, Levine DA, Rak J, Vanderhyden B, Foulkes WD, Huang S. Xue Y, et al. Among authors: pelletier j. Nat Commun. 2019 Feb 4;10(1):558. doi: 10.1038/s41467-018-06958-9. Nat Commun. 2019. PMID: 30718512 Free PMC article.
Identification and characterization of hippuristanol-resistant mutants reveals eIF4A1 dependencies within mRNA 5' leader regions.
Steinberger J, Shen L, J Kiniry S, Naineni SK, Cencic R, Amiri M, Aboushawareb SAE, Chu J, Maïga RI, Yachnin BJ, Robert F, Sonenberg N, Baranov PV, Pelletier J. Steinberger J, et al. Among authors: pelletier j, j kiniry s. Nucleic Acids Res. 2020 Sep 25;48(17):9521-9537. doi: 10.1093/nar/gkaa662. Nucleic Acids Res. 2020. PMID: 32766783 Free PMC article.
A forward genetic screen identifies modifiers of rocaglate responsiveness.
Shen L, Pugsley L, Cencic R, Wang H, Robert F, Naineni SK, Sahni A, Morin G, Zhang W, Nijnik A, Porco JA Jr, Langlais D, Huang S, Pelletier J. Shen L, et al. Among authors: pelletier j. Sci Rep. 2021 Sep 16;11(1):18516. doi: 10.1038/s41598-021-97765-8. Sci Rep. 2021. PMID: 34531456 Free PMC article.
Altering chemosensitivity by modulating translation elongation.
Robert F, Carrier M, Rawe S, Chen S, Lowe S, Pelletier J. Robert F, et al. Among authors: pelletier j. PLoS One. 2009;4(5):e5428. doi: 10.1371/journal.pone.0005428. Epub 2009 May 1. PLoS One. 2009. PMID: 19412536 Free PMC article.
1,991 results