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Nitric oxide synthase is present in the cerebrospinal fluid of patients with active multiple sclerosis and is associated with increases in cerebrospinal fluid protein nitrotyrosine and S-nitrosothiols and with changes in glutathione levels.
Calabrese V, Scapagnini G, Ravagna A, Bella R, Foresti R, Bates TE, Giuffrida Stella AM, Pennisi G. Calabrese V, et al. Among authors: pennisi g. J Neurosci Res. 2002 Nov 15;70(4):580-7. doi: 10.1002/jnr.10408. J Neurosci Res. 2002. PMID: 12404512 Clinical Trial.
Proteomics analysis provides insight into caloric restriction mediated oxidation and expression of brain proteins associated with age-related impaired cellular processes: Mitochondrial dysfunction, glutamate dysregulation and impaired protein synthesis.
Poon HF, Shepherd HM, Reed TT, Calabrese V, Stella AM, Pennisi G, Cai J, Pierce WM, Klein JB, Butterfield DA. Poon HF, et al. Among authors: pennisi g. Neurobiol Aging. 2006 Jul;27(7):1020-34. doi: 10.1016/j.neurobiolaging.2005.05.014. Epub 2005 Jul 5. Neurobiol Aging. 2006. PMID: 15996793
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