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Accumulation of APP C-terminal fragments causes endolysosomal dysfunction through the dysregulation of late endosome to lysosome-ER contact sites.
Dev Cell. 2024 Apr 12:S1534-5807(24)00199-0. doi: 10.1016/j.devcel.2024.03.030. Online ahead of print.
Dev Cell. 2024.
PMID: 38626765
Free article.
Phospholipase D3 degrades mitochondrial DNA to regulate nucleotide signaling and APP metabolism.
Van Acker ZP, Perdok A, Hellemans R, North K, Vorsters I, Cappel C, Dehairs J, Swinnen JV, Sannerud R, Bretou M, Damme M, Annaert W.
Van Acker ZP, et al. Among authors: perdok a.
Nat Commun. 2023 May 24;14(1):2847. doi: 10.1038/s41467-023-38501-w.
Nat Commun. 2023.
PMID: 37225734
Free PMC article.
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The microglial lysosomal system in Alzheimer's disease: Guardian against proteinopathy.
Van Acker ZP, Perdok A, Bretou M, Annaert W.
Van Acker ZP, et al. Among authors: perdok a.
Ageing Res Rev. 2021 Nov;71:101444. doi: 10.1016/j.arr.2021.101444. Epub 2021 Aug 12.
Ageing Res Rev. 2021.
PMID: 34391945
Review.
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