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Page 1
Mitochondrial mistranslation modulated by metabolic stress causes cardiovascular disease and reduced lifespan.
Richman TR, Ermer JA, Siira SJ, Kuznetsova I, Brosnan CA, Rossetti G, Baker J, Perks KL, Cserne Szappanos H, Viola HM, Gray N, Larance M, Hool LC, Zuryn S, Rackham O, Filipovska A. Richman TR, et al. Among authors: perks kl. Aging Cell. 2021 Jul;20(7):e13408. doi: 10.1111/acel.13408. Epub 2021 Jun 7. Aging Cell. 2021. PMID: 34096683 Free PMC article.
Stress signaling and cellular proliferation reverse the effects of mitochondrial mistranslation.
Ferreira N, Perks KL, Rossetti G, Rudler DL, Hughes LA, Ermer JA, Scott LH, Kuznetsova I, Richman TR, Narayana VK, Abudulai LN, Shearwood AJ, Cserne Szappanos H, Tull D, Yeoh GC, Hool LC, Filipovska A, Rackham O. Ferreira N, et al. Among authors: perks kl. EMBO J. 2019 Dec 16;38(24):e102155. doi: 10.15252/embj.2019102155. Epub 2019 Nov 13. EMBO J. 2019. PMID: 31721250 Free PMC article.
Adult-onset obesity is triggered by impaired mitochondrial gene expression.
Perks KL, Ferreira N, Richman TR, Ermer JA, Kuznetsova I, Shearwood AJ, Lee RG, Viola HM, Johnstone VPA, Matthews V, Hool LC, Rackham O, Filipovska A. Perks KL, et al. Sci Adv. 2017 Aug 16;3(8):e1700677. doi: 10.1126/sciadv.1700677. eCollection 2017 Aug. Sci Adv. 2017. PMID: 28835921 Free PMC article.
A common genetic variant of a mitochondrial RNA processing enzyme predisposes to insulin resistance.
Rossetti G, Ermer JA, Stentenbach M, Siira SJ, Richman TR, Milenkovic D, Perks KL, Hughes LA, Jamieson E, Xiafukaiti G, Ward NC, Takahashi S, Gray N, Viola HM, Hool LC, Rackham O, Filipovska A. Rossetti G, et al. Among authors: perks kl. Sci Adv. 2021 Sep 24;7(39):eabi7514. doi: 10.1126/sciadv.abi7514. Epub 2021 Sep 24. Sci Adv. 2021. PMID: 34559558 Free PMC article.
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