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Discovery of KRB-456, a KRAS G12D Switch-I/II Allosteric Pocket Binder That Inhibits the Growth of Pancreatic Cancer Patient-derived Tumors.
Kazi A, Ranjan A, Kumar M V V, Agianian B, Garcia Chavez M, Vudatha V, Wang R, Vangipurapu R, Chen L, Kennedy P, Subramanian K, Quirke JCK, Beato F, Underwood PW, Fleming JB, Trevino J, Hergenrother PJ, Gavathiotis E, Sebti SM. Kazi A, et al. Among authors: kennedy p. Cancer Res Commun. 2023 Dec 28;3(12):2623-2639. doi: 10.1158/2767-9764.CRC-23-0222. Cancer Res Commun. 2023. PMID: 38051103 Free PMC article.
Dual Farnesyl and Geranylgeranyl Transferase Inhibitor Thwarts Mutant KRAS-Driven Patient-Derived Pancreatic Tumors.
Kazi A, Xiang S, Yang H, Chen L, Kennedy P, Ayaz M, Fletcher S, Cummings C, Lawrence HR, Beato F, Kang Y, Kim MP, Delitto A, Underwood PW, Fleming JB, Trevino JG, Hamilton AD, Sebti SM. Kazi A, et al. Among authors: kennedy p. Clin Cancer Res. 2019 Oct 1;25(19):5984-5996. doi: 10.1158/1078-0432.CCR-18-3399. Epub 2019 Jun 21. Clin Cancer Res. 2019. PMID: 31227505 Free PMC article.
Characterization of a sphingosine 1-phosphate receptor antagonist prodrug.
Kennedy PC, Zhu R, Huang T, Tomsig JL, Mathews TP, David M, Peyruchaud O, Macdonald TL, Lynch KR. Kennedy PC, et al. J Pharmacol Exp Ther. 2011 Sep;338(3):879-89. doi: 10.1124/jpet.111.181552. Epub 2011 Jun 1. J Pharmacol Exp Ther. 2011. PMID: 21632869 Free PMC article.