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Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance.
Skovsø S, Panzhinskiy E, Kolic J, Cen HH, Dionne DA, Dai XQ, Sharma RB, Elghazi L, Ellis CE, Faulkner K, Marcil SAM, Overby P, Noursadeghi N, Hutchinson D, Hu X, Li H, Modi H, Wildi JS, Botezelli JD, Noh HL, Suk S, Gablaski B, Bautista A, Kim R, Cras-Méneur C, Flibotte S, Sinha S, Luciani DS, Nislow C, Rideout EJ, Cytrynbaum EN, Kim JK, Bernal-Mizrachi E, Alonso LC, MacDonald PE, Johnson JD. Skovsø S, et al. Among authors: overby p. Nat Commun. 2022 Feb 8;13(1):735. doi: 10.1038/s41467-022-28039-8. Nat Commun. 2022. PMID: 35136059 Free PMC article.
β-Cell Cre Expression and Reduced Ins1 Gene Dosage Protect Mice From Type 1 Diabetes.
Skovsø S, Overby P, Memar-Zadeh J, Lee JTC, Yang JCC, Shanina I, Sidarala V, Levi-D'Ancona E, Zhu J, Soleimanpour SA, Horwitz MS, Johnson JD. Skovsø S, et al. Among authors: overby p. Endocrinology. 2022 Oct 11;163(11):bqac144. doi: 10.1210/endocr/bqac144. Endocrinology. 2022. PMID: 36048448 Free PMC article.
Adipose depot-specific upregulation of Ucp1 or mitochondrial oxidative complex proteins are early consequences of genetic insulin reduction in mice.
Botezelli JD, Overby P, Lindo L, Wang S, Haïda O, Lim GE, Templeman NM, Pauli JR, Johnson JD. Botezelli JD, et al. Among authors: overby p. Am J Physiol Endocrinol Metab. 2020 Sep 1;319(3):E529-E539. doi: 10.1152/ajpendo.00128.2020. Epub 2020 Jul 27. Am J Physiol Endocrinol Metab. 2020. PMID: 32715748 Free article.
Inducible deletion of skeletal muscle AMPKα reveals that AMPK is required for nucleotide balance but dispensable for muscle glucose uptake and fat oxidation during exercise.
Hingst JR, Kjøbsted R, Birk JB, Jørgensen NO, Larsen MR, Kido K, Larsen JK, Kjeldsen SAS, Fentz J, Frøsig C, Holm S, Fritzen AM, Dohlmann TL, Larsen S, Foretz M, Viollet B, Schjerling P, Overby P, Halling JF, Pilegaard H, Hellsten Y, Wojtaszewski JFP. Hingst JR, et al. Among authors: overby p. Mol Metab. 2020 Oct;40:101028. doi: 10.1016/j.molmet.2020.101028. Epub 2020 Jun 3. Mol Metab. 2020. PMID: 32504885 Free PMC article.