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α/β-Peptide Foldamers Targeting Intracellular Protein-Protein Interactions with Activity in Living Cells.
Checco JW, Lee EF, Evangelista M, Sleebs NJ, Rogers K, Pettikiriarachchi A, Kershaw NJ, Eddinger GA, Belair DG, Wilson JL, Eller CH, Raines RT, Murphy WL, Smith BJ, Gellman SH, Fairlie WD. Checco JW, et al. Among authors: pettikiriarachchi a. J Am Chem Soc. 2015 Sep 9;137(35):11365-75. doi: 10.1021/jacs.5b05896. Epub 2015 Aug 28. J Am Chem Soc. 2015. PMID: 26317395 Free PMC article.
The functional differences between pro-survival and pro-apoptotic B cell lymphoma 2 (Bcl-2) proteins depend on structural differences in their Bcl-2 homology 3 (BH3) domains.
Lee EF, Dewson G, Evangelista M, Pettikiriarachchi A, Gold GJ, Zhu H, Colman PM, Fairlie WD. Lee EF, et al. Among authors: pettikiriarachchi a. J Biol Chem. 2014 Dec 26;289(52):36001-17. doi: 10.1074/jbc.M114.610758. Epub 2014 Nov 3. J Biol Chem. 2014. PMID: 25371206 Free PMC article.
The BECN1 N-terminal domain is intrinsically disordered.
Lee EF, Perugini MA, Pettikiriarachchi A, Evangelista M, Keizer DW, Yao S, Fairlie WD. Lee EF, et al. Among authors: pettikiriarachchi a. Autophagy. 2016;12(3):460-71. doi: 10.1080/15548627.2016.1140292. Autophagy. 2016. PMID: 27046249 Free PMC article.
Physiological restraint of Bak by Bcl-xL is essential for cell survival.
Lee EF, Grabow S, Chappaz S, Dewson G, Hockings C, Kluck RM, Debrincat MA, Gray DH, Witkowski MT, Evangelista M, Pettikiriarachchi A, Bouillet P, Lane RM, Czabotar PE, Colman PM, Smith BJ, Kile BT, Fairlie WD. Lee EF, et al. Among authors: pettikiriarachchi a. Genes Dev. 2016 May 15;30(10):1240-50. doi: 10.1101/gad.279414.116. Epub 2016 May 19. Genes Dev. 2016. PMID: 27198225 Free PMC article.
Structural insights into BCL2 pro-survival protein interactions with the key autophagy regulator BECN1 following phosphorylation by STK4/MST1.
Lee EF, Smith NA, Soares da Costa TP, Meftahi N, Yao S, Harris TJ, Tran S, Pettikiriarachchi A, Perugini MA, Keizer DW, Evangelista M, Smith BJ, Fairlie WD. Lee EF, et al. Among authors: pettikiriarachchi a. Autophagy. 2019 May;15(5):785-795. doi: 10.1080/15548627.2018.1564557. Epub 2019 Jan 9. Autophagy. 2019. PMID: 30626284 Free PMC article.
13 results