Pettit GR - Search Results

1

Dolastatin 10, a powerful cytostatic peptide derived from a marine animal. Inhibition of tubulin polymerization mediated through the vinca alkaloid binding domain.

Bai R, Pettit GR, Hamel E. Bai R, et al. Among authors: pettit gr. Biochem Pharmacol. 1990 Jun 15;39(12):1941-9. doi: 10.1016/0006-2952(90)90613-p. Biochem Pharmacol. 1990. PMID: 2353935

Dolastatin 10, a cytostatic peptide containing several unique amino acid subunits, was isolated from the marine shell-less mollusk Dolabella auricularia (Pettit GR, Kamano Y, Herald CL, Tuinman AA, Boettner FE, Kizu H, Schmidt JM, Baczynskyj L, Tomer KB and Bontems …

Dolastatin 10, a cytostatic peptide containing several unique amino acid subunits, was isolated from the marine shell-less mollusk Dolabella …

2

Spongistatin 1, a highly cytotoxic, sponge-derived, marine natural product that inhibits mitosis, microtubule assembly, and the binding of vinblastine to tubulin.

Bai R, Cichacz ZA, Herald CL, Pettit GR, Hamel E. Bai R, et al. Among authors: pettit gr. Mol Pharmacol. 1993 Oct;44(4):757-66. Mol Pharmacol. 1993. PMID: 8232226

3

Differential effects of active isomers, segments, and analogs of dolastatin 10 on ligand interactions with tubulin. Correlation with cytotoxicity.

Bai R, Roach MC, Jayaram SK, Barkoczy J, Pettit GR, Ludueña RF, Hamel E. Bai R, et al. Among authors: pettit gr. Biochem Pharmacol. 1993 Apr 6;45(7):1503-15. doi: 10.1016/0006-2952(93)90051-w. Biochem Pharmacol. 1993. PMID: 8471072

4

Characterization of the interaction of cryptophycin 1 with tubulin: binding in the Vinca domain, competitive inhibition of dolastatin 10 binding, and an unusual aggregation reaction.

Bai R, Schwartz RE, Kepler JA, Pettit GR, Hamel E. Bai R, et al. Among authors: pettit gr. Cancer Res. 1996 Oct 1;56(19):4398-406. Cancer Res. 1996. PMID: 8813133

5

Sustained intracellular retention of dolastatin 10 causes its potent antimitotic activity.

Verdier-Pinard P, Kepler JA, Pettit GR, Hamel E. Verdier-Pinard P, et al. Among authors: pettit gr. Mol Pharmacol. 2000 Jan;57(1):180-7. Mol Pharmacol. 2000. PMID: 10617693

6

Dolastatin 11, a marine depsipeptide, arrests cells at cytokinesis and induces hyperpolymerization of purified actin.

Bai R, Verdier-Pinard P, Gangwar S, Stessman CC, McClure KJ, Sausville EA, Pettit GR, Bates RB, Hamel E. Bai R, et al. Among authors: pettit gr. Mol Pharmacol. 2001 Mar;59(3):462-9. doi: 10.1124/mol.59.3.462. Mol Pharmacol. 2001. PMID: 11179440

7

Antineoplastic agents 337. Synthesis of dolastatin 10 structural modifications.

Pettit GR, Srirangam JK, Barkoczy J, Williams MD, Durkin KP, Boyd MR, Bai R, Hamel E, Schmidt JM, Chapuis JC. Pettit GR, et al. Anticancer Drug Des. 1995 Oct;10(7):529-44. Anticancer Drug Des. 1995. PMID: 7495477

8

The spongistatins, potently cytotoxic inhibitors of tubulin polymerization, bind in a distinct region of the vinca domain.

Bai R, Taylor GF, Cichacz ZA, Herald CL, Kepler JA, Pettit GR, Hamel E. Bai R, et al. Among authors: pettit gr. Biochemistry. 1995 Aug 1;34(30):9714-21. doi: 10.1021/bi00030a009. Biochemistry. 1995. PMID: 7626642

9

Interaction of dolastatin 10 with tubulin: induction of aggregation and binding and dissociation reactions.

Bai R, Taylor GF, Schmidt JM, Williams MD, Kepler JA, Pettit GR, Hamel E. Bai R, et al. Among authors: pettit gr. Mol Pharmacol. 1995 May;47(5):965-76. Mol Pharmacol. 1995. PMID: 7746283

10

Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data.

Bai RL, Paull KD, Herald CL, Malspeis L, Pettit GR, Hamel E. Bai RL, et al. Among authors: pettit gr. J Biol Chem. 1991 Aug 25;266(24):15882-9. J Biol Chem. 1991. PMID: 1874739 Free article.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

463 results

Search Page