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Biosynthesis of the C(7)-cyclitol moiety of acarbose in Actinoplanes species SE50/110. 7-O-phosphorylation of the initial cyclitol precursor leads to proposal of a new biosynthetic pathway.
Zhang CS, Stratmann A, Block O, Brückner R, Podeschwa M, Altenbach HJ, Wehmeier UF, Piepersberg W. Zhang CS, et al. Among authors: piepersberg w. J Biol Chem. 2002 Jun 21;277(25):22853-62. doi: 10.1074/jbc.M202375200. Epub 2002 Apr 5. J Biol Chem. 2002. PMID: 11937512 Free article.
The StrQ protein encoded in the gene cluster for 5'-hydroxystreptomycin of Streptomyces glaucescens GLA.0 is a alpha-D-glucose-1-phosphate cytidylyltransferase (CDP-D-glucose synthase).
Beyer S, Mayer G, Piepersberg W. Beyer S, et al. Among authors: piepersberg w. Eur J Biochem. 1998 Dec 15;258(3):1059-67. doi: 10.1046/j.1432-1327.1998.2581059.x. Eur J Biochem. 1998. PMID: 9990325 Free article.
[In contrast, the corresponding operon in the str/sts-gene cluster of the Sm-producer Streptomyces griseus, strB1FGHIK, differs in the two distal genes; Mansouri, K. & Piepersberg, W. (1991) Mol. Gen. Genet. 228, 459-469]. The deduced StrQ protein exhibited simi …
[In contrast, the corresponding operon in the str/sts-gene cluster of the Sm-producer Streptomyces griseus, strB1FGHIK, differs in the two d …
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