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The SARS-CoV-2 monoclonal antibody combination, AZD7442, is protective in nonhuman primates and has an extended half-life in humans.
Loo YM, McTamney PM, Arends RH, Abram ME, Aksyuk AA, Diallo S, Flores DJ, Kelly EJ, Ren K, Roque R, Rosenthal K, Streicher K, Tuffy KM, Bond NJ, Cornwell O, Bouquet J, Cheng LI, Dunyak J, Huang Y, Rosenbaum AI, Pilla Reddy V, Andersen H, Carnahan RH, Crowe JE Jr, Kuehne AI, Herbert AS, Dye JM, Bright H, Kallewaard NL, Pangalos MN, Esser MT. Loo YM, et al. Among authors: pilla reddy v. Sci Transl Med. 2022 Mar 9;14(635):eabl8124. doi: 10.1126/scitranslmed.abl8124. Epub 2022 Mar 9. Sci Transl Med. 2022. PMID: 35076282 Free PMC article.
Comparing the applications of machine learning, PBPK, and population pharmacokinetic models in pharmacokinetic drug-drug interaction prediction.
Gill J, Moullet M, Martinsson A, Miljković F, Williamson B, Arends RH, Pilla Reddy V. Gill J, et al. Among authors: pilla reddy v. CPT Pharmacometrics Syst Pharmacol. 2022 Dec;11(12):1560-1568. doi: 10.1002/psp4.12870. Epub 2022 Oct 12. CPT Pharmacometrics Syst Pharmacol. 2022. PMID: 36176050 Free PMC article. Review.
ALT neuroblastoma chemoresistance due to telomere dysfunction-induced ATM activation is reversible with ATM inhibitor AZD0156.
Koneru B, Farooqi A, Nguyen TH, Chen WH, Hindle A, Eslinger C, Makena MR, Burrow TA, Wilson J, Smith A, Pilla Reddy V, Cadogan E, Durant ST, Reynolds CP. Koneru B, et al. Among authors: pilla reddy v. Sci Transl Med. 2021 Aug 18;13(607):eabd5750. doi: 10.1126/scitranslmed.abd5750. Sci Transl Med. 2021. PMID: 34408079 Free PMC article.
Comparative Pharmacokinetics of Tixagevimab/Cilgavimab (AZD7442) Administered Intravenously Versus Intramuscularly in Symptomatic SARS-CoV-2 Infection.
Bender Ignacio RA, Wohl DA, Arends R, Pilla Reddy V, Mu Y, Javan AC, Hughes MD, Eron JJ, Currier JS, Smith D, Chew KW, Gibbs M, Fletcher CV. Bender Ignacio RA, et al. Among authors: pilla reddy v. Clin Pharmacol Ther. 2022 Dec;112(6):1207-1213. doi: 10.1002/cpt.2706. Epub 2022 Jul 26. Clin Pharmacol Ther. 2022. PMID: 35797235 Free PMC article. Clinical Trial.
Pharmacokinetics under the COVID-19 storm.
Pilla Reddy V, El-Khateeb E, Jo H, Giovino N, Lythgoe E, Sharma S, Tang W, Jamei M, Rastomi-Hodjegan A. Pilla Reddy V, et al. Br J Clin Pharmacol. 2023 Jan;89(1):158-186. doi: 10.1111/bcp.14668. Epub 2021 Jan 14. Br J Clin Pharmacol. 2023. PMID: 33226664 Free PMC article.
42 results