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Identification of a selective inhibitor of murine intestinal alkaline phosphatase (ML260) by concurrent ultra-high throughput screening against human and mouse isozymes.
Ardecky RJ, Bobkova EV, Kiffer-Moreira T, Brown B, Ganji S, Zou J, Pass I, Narisawa S, Iano FG, Rosenstein C, Cheltsov A, Rascon J, Hedrick M, Gasior C, Forster A, Shi S, Dahl R, Vasile S, Su Y, Sergienko E, Chung TDY, Kaunitz J, Hoylaerts MF, Pinkerton AB, Millán JL. Ardecky RJ, et al. Among authors: pinkerton ab. Bioorg Med Chem Lett. 2014 Feb 1;24(3):1000-1004. doi: 10.1016/j.bmcl.2013.12.043. Epub 2013 Dec 19. Bioorg Med Chem Lett. 2014. PMID: 24412070 Free PMC article.
Overexpression of tissue-nonspecific alkaline phosphatase (TNAP) in endothelial cells accelerates coronary artery disease in a mouse model of familial hypercholesterolemia.
Romanelli F, Corbo A, Salehi M, Yadav MC, Salman S, Petrosian D, Rashidbaigi OJ, Chait J, Kuruvilla J, Plummer M, Radichev I, Margulies KB, Gerdes AM, Pinkerton AB, Millán JL, Savinov AY, Savinova OV. Romanelli F, et al. Among authors: pinkerton ab. PLoS One. 2017 Oct 12;12(10):e0186426. doi: 10.1371/journal.pone.0186426. eCollection 2017. PLoS One. 2017. PMID: 29023576 Free PMC article.
Loss of tissue-nonspecific alkaline phosphatase (TNAP) enzyme activity in cerebral microvessels is coupled to persistent neuroinflammation and behavioral deficits in late sepsis.
Nwafor DC, Chakraborty S, Brichacek AL, Jun S, Gambill CA, Wang W, Engler-Chiurazzi EB, Dakhlallah D, Pinkerton AB, Millán JL, Benkovic SA, Brown CM. Nwafor DC, et al. Among authors: pinkerton ab. Brain Behav Immun. 2020 Feb;84:115-131. doi: 10.1016/j.bbi.2019.11.016. Epub 2019 Nov 25. Brain Behav Immun. 2020. PMID: 31778743 Free PMC article.
103 results