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Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors.
Specker E, Wesolowski R, Schütz A, Matthes S, Mallow K, Wasinska-Kalwa M, Winkler L, Oder A, Alenina N, Pleimes D, von Kries JP, Heinemann U, Bader M, Nazaré M. Specker E, et al. Among authors: pleimes d. J Med Chem. 2023 Nov 9;66(21):14866-14896. doi: 10.1021/acs.jmedchem.3c01454. Epub 2023 Oct 31. J Med Chem. 2023. PMID: 37905925
Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors.
Specker E, Matthes S, Wesolowski R, Schütz A, Grohmann M, Alenina N, Pleimes D, Mallow K, Neuenschwander M, Gogolin A, Weise M, Pfeifer J, Ziebart N, Heinemann U, von Kries JP, Nazaré M, Bader M. Specker E, et al. Among authors: pleimes d. J Med Chem. 2022 Aug 25;65(16):11126-11149. doi: 10.1021/acs.jmedchem.2c00598. Epub 2022 Aug 3. J Med Chem. 2022. PMID: 35921615
Delayed renal injury in survivors of hematologic acute radiation syndrome.
Gasperetti T, Frei A, Prasad Sharma G, Pierce L, Veley D, Szalewski N, Munjal Mehta S, Fish BL, Pleimes D, Himburg HA. Gasperetti T, et al. Among authors: pleimes d. Int J Radiat Biol. 2023;99(7):1130-1138. doi: 10.1080/09553002.2023.2170491. Epub 2023 Jan 25. Int J Radiat Biol. 2023. PMID: 36688956 Free PMC article.
The 11-year long-term follow-up study from the randomized BENEFIT CIS trial.
Kappos L, Edan G, Freedman MS, Montalbán X, Hartung HP, Hemmer B, Fox EJ, Barkhof F, Schippling S, Schulze A, Pleimes D, Pohl C, Sandbrink R, Suarez G, Wicklein EM; BENEFIT Study Group. Kappos L, et al. Among authors: pleimes d. Neurology. 2016 Sep 6;87(10):978-87. doi: 10.1212/WNL.0000000000003078. Epub 2016 Aug 10. Neurology. 2016. PMID: 27511182 Free PMC article. Clinical Trial.
Molecular mechanism underlying the impact of vitamin D on disease activity of MS.
Munger KL, Köchert K, Simon KC, Kappos L, Polman CH, Freedman MS, Hartung HP, Miller DH, Montalbán X, Edan G, Barkhof F, Pleimes D, Sandbrink R, Ascherio A, Pohl C. Munger KL, et al. Among authors: pleimes d. Ann Clin Transl Neurol. 2014 Aug;1(8):605-17. doi: 10.1002/acn3.91. Epub 2014 Aug 22. Ann Clin Transl Neurol. 2014. PMID: 25285313 Free PMC article.
19 results