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Page 1
Showing results for podocytes')
Search for Podoces') instead (3 results)
Are podocytes motile?
Endlich N, Siegerist F, Endlich K. Endlich N, et al. Pflugers Arch. 2017 Aug;469(7-8):951-957. doi: 10.1007/s00424-017-2016-9. Epub 2017 Jun 24. Pflugers Arch. 2017. PMID: 28647853 Review.
Such motility would also be the prerequisite for the replacement of lost podocytes by progenitor cells. Additionally, the change of the podocyte foot processes from a normal to an effaced morphology, like it is found in many kidney diseases, would require a dynamic …
Such motility would also be the prerequisite for the replacement of lost podocytes by progenitor cells. Additionally, the change of t …
Role of actin cytoskeleton in podocytes.
Sever S. Sever S. Pediatr Nephrol. 2021 Sep;36(9):2607-2614. doi: 10.1007/s00467-020-04812-z. Epub 2020 Nov 13. Pediatr Nephrol. 2021. PMID: 33188449 Free PMC article. Review.
One of the earliest signs of podocyte injury is loss of their distinct structure, which is driven by dysregulated dynamics of the actin cytoskeleton. ...In addition, a growing body of studies suggest that pharmacological modifications of the actin cytoskeleton have the pot …
One of the earliest signs of podocyte injury is loss of their distinct structure, which is driven by dysregulated dynamics of the act …
Podocytes from the diagnostic and therapeutic point of view.
Müller-Deile J, Schiffer M. Müller-Deile J, et al. Pflugers Arch. 2017 Aug;469(7-8):1007-1015. doi: 10.1007/s00424-017-1993-z. Epub 2017 May 16. Pflugers Arch. 2017. PMID: 28508947 Review.
In this review, we discuss the current literature on the use of podocytes and podocyte-specific markers as non-invasive diagnostic tools in different glomerulopathies. Furthermore, we highlight the direct effects of drugs currently used to treat primary glomerular d …
In this review, we discuss the current literature on the use of podocytes and podocyte-specific markers as non-invasive diagno …
Can podocytes be regenerated in adults?
Shankland SJ, Freedman BS, Pippin JW. Shankland SJ, et al. Curr Opin Nephrol Hypertens. 2017 May;26(3):154-164. doi: 10.1097/MNH.0000000000000311. Curr Opin Nephrol Hypertens. 2017. PMID: 28306565 Free PMC article. Review.
Terminally differentiated adult podocytes are highly specialized, postmitotic cells, raising the question of whether the body has any ability to regenerate lost podocytes. ...RECENT FINDINGS: The innovation of genetic labeling techniques enables fate tracing of indi …
Terminally differentiated adult podocytes are highly specialized, postmitotic cells, raising the question of whether the body has any …
Stressed podocytes-mechanical forces, sensors, signaling and response.
Endlich K, Kliewe F, Endlich N. Endlich K, et al. Pflugers Arch. 2017 Aug;469(7-8):937-949. doi: 10.1007/s00424-017-2025-8. Epub 2017 Jul 7. Pflugers Arch. 2017. PMID: 28687864 Review.
In vitro evidence documents that podocytes respond to tensile stress as well as to fluid shear stress. ...Membrane, slit diaphragm and cell-matrix contact proteins are connected to the sublemmal actin network in podocytes via various linker proteins. Therefore, acti …
In vitro evidence documents that podocytes respond to tensile stress as well as to fluid shear stress. ...Membrane, slit diaphragm an …
The mechanobiology of kidney podocytes in health and disease.
Reynolds PA. Reynolds PA. Clin Sci (Lond). 2020 Jun 12;134(11):1245-1253. doi: 10.1042/CS20190764. Clin Sci (Lond). 2020. PMID: 32501496 Review.
During aging, some podocytes are lost naturally but accelerated podocyte loss is a hallmark of CKD. ...Here, approaches that uncover insights into podocyte mechanobiology are reviewed, both those that interrogate the biophysical properties of podocytes …
During aging, some podocytes are lost naturally but accelerated podocyte loss is a hallmark of CKD. ...Here, approaches that u …
Podocytes and the quest for precision medicines for kidney diseases.
Mundel P. Mundel P. Pflugers Arch. 2017 Aug;469(7-8):1029-1037. doi: 10.1007/s00424-017-2015-x. Epub 2017 Jun 23. Pflugers Arch. 2017. PMID: 28646406 Review.
We were not aware of genetic causes or drivers of kidney diseases nor of molecular markers and cell culture systems for mechanistic studies of podocyte biology. Tools for generating podocyte-specific knockout mice did not exist, and the key role of the podocyte …
We were not aware of genetic causes or drivers of kidney diseases nor of molecular markers and cell culture systems for mechanistic studies …
The Physiopathologic Roles of Calcium Signaling in Podocytes.
Tu YC, Shu HP, Sun LL, Liao QQ, Feng L, Ren M, Yao LJ. Tu YC, et al. Front Biosci (Landmark Ed). 2023 Oct 18;28(10):240. doi: 10.31083/j.fbl2810240. Front Biosci (Landmark Ed). 2023. PMID: 37919067 Free article. Review.
Calcium (Ca2+) plays a critical role in podocyte function. The Ca2+-sensitive receptors on the cell surface can sense changes in Ca2+ concentration, and Ca2+ flow into podocytes, after activation of Ca2+ channels (such as transient receptor potential canonical (TRPC …
Calcium (Ca2+) plays a critical role in podocyte function. The Ca2+-sensitive receptors on the cell surface can sense changes in Ca2+ …
Podocytes: recent biomolecular developments.
Armelloni S, Corbelli A, Giardino L, Li M, Ikehata M, Mattinzoli D, Messa P, Pignatari C, Watanabe S, Rastaldi MP. Armelloni S, et al. Biomol Concepts. 2014 Aug;5(4):319-30. doi: 10.1515/bmc-2014-0020. Biomol Concepts. 2014. PMID: 25372762 Free article. Review.
Podocytes are postmitotic renal glomerular cells with multiple ramifications that extend from the cell body. ...In the last 15 years, progressive technological advances have aided the study of podocyte biology and pathology, confirming the relevance of podocyte …
Podocytes are postmitotic renal glomerular cells with multiple ramifications that extend from the cell body. ...In the last 15 years, …
Podocytes as a target of insulin.
Coward RJ, Saleem MA. Coward RJ, et al. Curr Diabetes Rev. 2011 Jan;7(1):22-7. doi: 10.2174/157339911794273883. Curr Diabetes Rev. 2011. PMID: 21067503 Review.
How these cellular features are damaged by the diabetic milieu is unclear, but what is becoming increasingly clear is that damage to the podocyte is a central event in DN. Here we present accumulating evidence that insulin action itself is important in podocyte biol …
How these cellular features are damaged by the diabetic milieu is unclear, but what is becoming increasingly clear is that damage to the …
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