Politi KA - Search Results

1

Update on epidermal growth factor receptor mutations in non-small cell lung cancer.

Riely GJ, Politi KA, Miller VA, Pao W. Riely GJ, et al. Among authors: politi ka. Clin Cancer Res. 2006 Dec 15;12(24):7232-41. doi: 10.1158/1078-0432.CCR-06-0658. Clin Cancer Res. 2006. PMID: 17189394 Review.

2

EGFR-driven lung adenocarcinomas coopt alveolar macrophage metabolism and function to support EGFR signaling and growth.

Kuhlmann-Hogan A, Cordes T, Xu Z, Kuna RS, Traina KA, Robles-Oteiza C, Ayeni D, Kwong EM, Levy S, Globig AM, Nobari MM, Cheng GZ, Leibel SL, Homer RJ, Shaw RJ, Metallo CM, Politi K, Kaech SM. Kuhlmann-Hogan A, et al. Among authors: politi k. Cancer Discov. 2024 Jan 19. doi: 10.1158/2159-8290.CD-23-0434. Online ahead of print. Cancer Discov. 2024. PMID: 38241033

3

Oncogenic context shapes the fitness landscape of tumor suppression.

Blair LM, Juan JM, Sebastian L, Tran VB, Nie W, Wall GD, Gerceker M, Lai IK, Apilado EA, Grenot G, Amar D, Foggetti G, Do Carmo M, Ugur Z, Deng D, Chenchik A, Paz Zafra M, Dow LE, Politi K, MacQuitty JJ, Petrov DA, Winslow MM, Rosen MJ, Winters IP. Blair LM, et al. Nat Commun. 2023 Oct 12;14(1):6422. doi: 10.1038/s41467-023-42156-y. Nat Commun. 2023. PMID: 37828026 Free PMC article.

4

EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib.

Pao W, Miller V, Zakowski M, Doherty J, Politi K, Sarkaria I, Singh B, Heelan R, Rusch V, Fulton L, Mardis E, Kupfer D, Wilson R, Kris M, Varmus H. Pao W, et al. Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13306-11. doi: 10.1073/pnas.0405220101. Epub 2004 Aug 25. Proc Natl Acad Sci U S A. 2004. PMID: 15329413 Free PMC article.

5

Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain.

Pao W, Miller VA, Politi KA, Riely GJ, Somwar R, Zakowski MF, Kris MG, Varmus H. Pao W, et al. Among authors: politi ka. PLoS Med. 2005 Mar;2(3):e73. doi: 10.1371/journal.pmed.0020073. Epub 2005 Feb 22. PLoS Med. 2005. PMID: 15737014 Free PMC article.

6

Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors.

Politi K, Zakowski MF, Fan PD, Schonfeld EA, Pao W, Varmus HE. Politi K, et al. Genes Dev. 2006 Jun 1;20(11):1496-510. doi: 10.1101/gad.1417406. Epub 2006 May 16. Genes Dev. 2006. PMID: 16705038 Free PMC article.

7

Oncogenes come of age.

Varmus H, Pao W, Politi K, Podsypanina K, Du YC. Varmus H, et al. Cold Spring Harb Symp Quant Biol. 2005;70:1-9. doi: 10.1101/sqb.2005.70.039. Cold Spring Harb Symp Quant Biol. 2005. PMID: 16869733 Free PMC article. Review.

8

BAC consensus conference, November 4-6, 2004: epidemiology, pathogenesis, and preclinical models.

Christiani DC, Pao W, DeMartini JC, Linnoila RI, Malkinson AM, Onn A, Politi KA, Sharp M, Wong KK. Christiani DC, et al. Among authors: politi ka. J Thorac Oncol. 2006 Nov;1(9 Suppl):S2-7. J Thorac Oncol. 2006. PMID: 17409996 Free article.

9

Development of new mouse lung tumor models expressing EGFR T790M mutants associated with clinical resistance to kinase inhibitors.

Regales L, Balak MN, Gong Y, Politi K, Sawai A, Le C, Koutcher JA, Solit DB, Rosen N, Zakowski MF, Pao W. Regales L, et al. PLoS One. 2007 Aug 29;2(8):e810. doi: 10.1371/journal.pone.0000810. PLoS One. 2007. PMID: 17726540 Free PMC article.

10

Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas.

Gong Y, Somwar R, Politi K, Balak M, Chmielecki J, Jiang X, Pao W. Gong Y, et al. PLoS Med. 2007 Oct 9;4(10):e294. doi: 10.1371/journal.pmed.0040294. PLoS Med. 2007. PMID: 17927446 Free PMC article.

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