Polli JW - Search Results

1

P-glycoprotein influences the brain concentrations of cetirizine (Zyrtec), a second-generation non-sedating antihistamine.

Polli JW, Baughman TM, Humphreys JE, Jordan KH, Mote AL, Salisbury JA, Tippin TK, Serabjit-Singh CJ. Polli JW, et al. J Pharm Sci. 2003 Oct;92(10):2082-9. doi: 10.1002/jps.10453. J Pharm Sci. 2003. PMID: 14502547

2

Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs.

Mahar Doan KM, Humphreys JE, Webster LO, Wring SA, Shampine LJ, Serabjit-Singh CJ, Adkison KK, Polli JW. Mahar Doan KM, et al. Among authors: polli jw. J Pharmacol Exp Ther. 2002 Dec;303(3):1029-37. doi: 10.1124/jpet.102.039255. J Pharmacol Exp Ther. 2002. PMID: 12438524

3

Predicting P-glycoprotein substrates by a quantitative structure-activity relationship model.

Gombar VK, Polli JW, Humphreys JE, Wring SA, Serabjit-Singh CS. Gombar VK, et al. Among authors: polli jw. J Pharm Sci. 2004 Apr;93(4):957-68. doi: 10.1002/jps.20035. J Pharm Sci. 2004. PMID: 14999732

4

The systemic exposure of an N-methyl-D-aspartate receptor antagonist is limited in mice by the P-glycoprotein and breast cancer resistance protein efflux transporters.

Polli JW, Baughman TM, Humphreys JE, Jordan KH, Mote AL, Webster LO, Barnaby RJ, Vitulli G, Bertolotti L, Read KD, Serabjit-Singh CJ. Polli JW, et al. Drug Metab Dispos. 2004 Jul;32(7):722-6. doi: 10.1124/dmd.32.7.722. Drug Metab Dispos. 2004. PMID: 15205387

5

Steady-state brain concentrations of antihistamines in rats: interplay of membrane permeability, P-glycoprotein efflux and plasma protein binding.

Mahar Doan KM, Wring SA, Shampine LJ, Jordan KH, Bishop JP, Kratz J, Yang E, Serabjit-Singh CJ, Adkison KK, Polli JW. Mahar Doan KM, et al. Among authors: polli jw. Pharmacology. 2004 Oct;72(2):92-8. doi: 10.1159/000079137. Pharmacology. 2004. PMID: 15331914

6

In vitro absorption and secretory quotients: practical criteria derived from a study of 331 compounds to assess for the impact of P-glycoprotein-mediated efflux on drug candidates.

Thiel-Demby VE, Tippin TK, Humphreys JE, Serabjit-Singh CJ, Polli JW. Thiel-Demby VE, et al. Among authors: polli jw. J Pharm Sci. 2004 Oct;93(10):2567-72. doi: 10.1002/jps.20166. J Pharm Sci. 2004. PMID: 15349966

7

In vitro p-glycoprotein inhibition assays for assessment of clinical drug interaction potential of new drug candidates: a recommendation for probe substrates.

Rautio J, Humphreys JE, Webster LO, Balakrishnan A, Keogh JP, Kunta JR, Serabjit-Singh CJ, Polli JW. Rautio J, et al. Among authors: polli jw. Drug Metab Dispos. 2006 May;34(5):786-92. doi: 10.1124/dmd.105.008615. Epub 2006 Feb 2. Drug Metab Dispos. 2006. PMID: 16455806

8

The role of efflux and uptake transporters in [N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine (GW572016, lapatinib) disposition and drug interactions.

Polli JW, Humphreys JE, Harmon KA, Castellino S, O'Mara MJ, Olson KL, John-Williams LS, Koch KM, Serabjit-Singh CJ. Polli JW, et al. Drug Metab Dispos. 2008 Apr;36(4):695-701. doi: 10.1124/dmd.107.018374. Epub 2008 Jan 23. Drug Metab Dispos. 2008. PMID: 18216274

9

Biopharmaceutics classification system: validation and learnings of an in vitro permeability assay.

Thiel-Demby VE, Humphreys JE, St John Williams LA, Ellens HM, Shah N, Ayrton AD, Polli JW. Thiel-Demby VE, et al. Among authors: polli jw. Mol Pharm. 2009 Jan-Feb;6(1):11-8. doi: 10.1021/mp800122b. Mol Pharm. 2009. PMID: 19248229

10

Oral sulfasalazine as a clinical BCRP probe substrate: pharmacokinetic effects of genetic variation (C421A) and pantoprazole coadministration.

Adkison KK, Vaidya SS, Lee DY, Koo SH, Li L, Mehta AA, Gross AS, Polli JW, Humphreys JE, Lou Y, Lee EJ. Adkison KK, et al. Among authors: polli jw. J Pharm Sci. 2010 Feb;99(2):1046-62. doi: 10.1002/jps.21860. J Pharm Sci. 2010. PMID: 19569219

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