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Orally active non-peptide fibrinogen receptor (GpIIb/IIIa) antagonists: identification of 4-[4-[4-(aminoiminomethyl)phenyl]-1-piperazinyl]-1-piperidineacetic acid as a long-acting, broad-spectrum antithrombotic agent.
Eldred CD, Evans B, Hindley S, Judkins BD, Kelly HA, Kitchin J, Lumley P, Porter B, Ross BC, Smith KJ, et al. Eldred CD, et al. Among authors: porter b. J Med Chem. 1994 Nov 11;37(23):3882-5. doi: 10.1021/jm00049a006. J Med Chem. 1994. PMID: 7966149 No abstract available.
The discovery of RPR 200765A, a p38 MAP kinase inhibitor displaying a good oral anti-arthritic efficacy.
Mclay LM, Halley F, Souness JE, McKenna J, Benning V, Birrell M, Burton B, Belvisi M, Collis A, Constan A, Foster M, Hele D, Jayyosi Z, Kelley M, Maslen C, Miller G, Ouldelhkim MC, Page K, Phipps S, Pollock K, Porter B, Ratcliffe AJ, Redford EJ, Webber S, Slater B, Thybaud V, Wilsher N. Mclay LM, et al. Among authors: porter b. Bioorg Med Chem. 2001 Feb;9(2):537-54. doi: 10.1016/s0968-0896(00)00331-x. Bioorg Med Chem. 2001. PMID: 11249145
Identification of a non peptidic RANTES antagonist.
Bright C, Brown TJ, Cox P, Halley F, Lockey P, McLay IM, Moore U, Porter B, Williams RJ. Bright C, et al. Among authors: porter b. Bioorg Med Chem Lett. 1998 Apr 7;8(7):771-4. doi: 10.1016/s0960-894x(98)00094-8. Bioorg Med Chem Lett. 1998. PMID: 9871539
853 results