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In vivo α-hydroxylation of a 2-alkylindole antagonist of the OXE receptor for the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid in monkeys.
Chourey S, Ye Q, Reddy CN, Cossette C, Gravel S, Zeller M, Slobodchikova I, Vuckovic D, Rokach J, Powell WS. Chourey S, et al. Among authors: powell ws. Biochem Pharmacol. 2017 Aug 15;138:107-118. doi: 10.1016/j.bcp.2017.04.031. Epub 2017 May 3. Biochem Pharmacol. 2017. PMID: 28476332 Free PMC article.
Pharmacokinetics and Metabolism of Selective Oxoeicosanoid (OXE) Receptor Antagonists and Their Effects on 5-Oxo-6,8,11,14-eicosatetraenoic Acid (5-Oxo-ETE)-Induced Granulocyte Activation in Monkeys.
Cossette C, Chourey S, Ye Q, Nagendra Reddy C, Gore V, Gravel S, Slobodchikova I, Vuckovic D, Rokach J, Powell WS. Cossette C, et al. Among authors: powell ws. J Med Chem. 2016 Nov 23;59(22):10127-10146. doi: 10.1021/acs.jmedchem.6b00895. Epub 2016 Nov 7. J Med Chem. 2016. PMID: 27766872
Novel Highly Potent and Metabolically Resistant Oxoeicosanoid (OXE) Receptor Antagonists That Block the Actions of the Granulocyte Chemoattractant 5-Oxo-6,8,11,14-Eicosatetraenoic Acid (5-oxo-ETE).
Chourey S, Ye Q, Reddy CN, Wang R, Cossette C, Gravel S, Slobodchikova I, Vuckovic D, Rokach J, Powell WS. Chourey S, et al. Among authors: powell ws. J Med Chem. 2018 Jul 26;61(14):5934-5948. doi: 10.1021/acs.jmedchem.8b00154. Epub 2018 Jul 17. J Med Chem. 2018. PMID: 29972644
181 results