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A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics.
Si L, Bai H, Rodas M, Cao W, Oh CY, Jiang A, Moller R, Hoagland D, Oishi K, Horiuchi S, Uhl S, Blanco-Melo D, Albrecht RA, Liu WC, Jordan T, Nilsson-Payant BE, Golynker I, Frere J, Logue J, Haupt R, McGrath M, Weston S, Zhang T, Plebani R, Soong M, Nurani A, Kim SM, Zhu DY, Benam KH, Goyal G, Gilpin SE, Prantil-Baun R, Gygi SP, Powers RK, Carlson KE, Frieman M, tenOever BR, Ingber DE. Si L, et al. Among authors: powers rk. Nat Biomed Eng. 2021 Aug;5(8):815-829. doi: 10.1038/s41551-021-00718-9. Epub 2021 May 3. Nat Biomed Eng. 2021. PMID: 33941899 Free PMC article.
Nutritional deficiency in an intestine-on-a-chip recapitulates injury hallmarks associated with environmental enteric dysfunction.
Bein A, Fadel CW, Swenor B, Cao W, Powers RK, Camacho DM, Naziripour A, Parsons A, LoGrande N, Sharma S, Kim S, Jalili-Firoozinezhad S, Grant J, Breault DT, Iqbal J, Ali A, Denson LA, Moore SR, Prantil-Baun R, Goyal G, Ingber DE. Bein A, et al. Among authors: powers rk. Nat Biomed Eng. 2022 Nov;6(11):1236-1247. doi: 10.1038/s41551-022-00899-x. Epub 2022 Jun 23. Nat Biomed Eng. 2022. PMID: 35739419 Free PMC article.
Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients.
Sperry MM, Oskotsky TT, Marić I, Kaushal S, Takeda T, Horvath V, Powers RK, Rodas M, Furlong B, Soong M, Prabhala P, Goyal G, Carlson KE, Wong RJ, Kosti I, Le BL, Logue J, Hammond H, Frieman M, Stevenson DK, Ingber DE, Sirota M, Novak R. Sperry MM, et al. Among authors: powers rk. PLoS Comput Biol. 2023 May 5;19(5):e1011050. doi: 10.1371/journal.pcbi.1011050. eCollection 2023 May. PLoS Comput Biol. 2023. PMID: 37146076 Free PMC article.
Next-Generation Machine Learning for Biological Networks.
Camacho DM, Collins KM, Powers RK, Costello JC, Collins JJ. Camacho DM, et al. Among authors: powers rk. Cell. 2018 Jun 14;173(7):1581-1592. doi: 10.1016/j.cell.2018.05.015. Epub 2018 Jun 7. Cell. 2018. PMID: 29887378 Free article. Review.
Metastatic cells are preferentially vulnerable to lysosomal inhibition.
Morgan MJ, Fitzwalter BE, Owens CR, Powers RK, Sottnik JL, Gamez G, Costello JC, Theodorescu D, Thorburn A. Morgan MJ, et al. Among authors: powers rk. Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):E8479-E8488. doi: 10.1073/pnas.1706526115. Epub 2018 Aug 20. Proc Natl Acad Sci U S A. 2018. PMID: 30127018 Free PMC article.
Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors.
Powers RK, Culp-Hill R, Ludwig MP, Smith KP, Waugh KA, Minter R, Tuttle KD, Lewis HC, Rachubinski AL, Granrath RE, Carmona-Iragui M, Wilkerson RB, Kahn DE, Joshi M, Lleó A, Blesa R, Fortea J, D'Alessandro A, Costello JC, Sullivan KD, Espinosa JM. Powers RK, et al. Nat Commun. 2019 Oct 18;10(1):4766. doi: 10.1038/s41467-019-12739-9. Nat Commun. 2019. PMID: 31628327 Free PMC article.
89 results