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Page 1
From fragment screening to in vivo efficacy: optimization of a series of 2-aminoquinolines as potent inhibitors of beta-site amyloid precursor protein cleaving enzyme 1 (BACE1).
Cheng Y, Judd TC, Bartberger MD, Brown J, Chen K, Fremeau RT Jr, Hickman D, Hitchcock SA, Jordan B, Li V, Lopez P, Louie SW, Luo Y, Michelsen K, Nixey T, Powers TS, Rattan C, Sickmier EA, St Jean DJ Jr, Wahl RC, Wen PH, Wood S. Cheng Y, et al. Among authors: powers ts. J Med Chem. 2011 Aug 25;54(16):5836-57. doi: 10.1021/jm200544q. Epub 2011 Jul 29. J Med Chem. 2011. PMID: 21707077
Development of 2-aminooxazoline 3-azaxanthenes as orally efficacious β-secretase inhibitors for the potential treatment of Alzheimer's disease.
Chen JJ, Liu Q, Yuan C, Gore V, Lopez P, Ma V, Amegadzie A, Qian W, Judd TC, Minatti AE, Brown J, Cheng Y, Xue M, Zhong W, Dineen TA, Epstein O, Human J, Kreiman C, Marx I, Weiss MM, Hitchcock SA, Powers TS, Chen K, Wen PH, Whittington DA, Cheng AC, Bartberger MD, Hickman D, Werner JA, Vargas HM, Everds NE, Vonderfecht SL, Dunn RT 2nd, Wood S, Fremeau RT Jr, White RD, Patel VF. Chen JJ, et al. Among authors: powers ts. Bioorg Med Chem Lett. 2015 Feb 15;25(4):767-74. doi: 10.1016/j.bmcl.2014.12.092. Epub 2015 Jan 8. Bioorg Med Chem Lett. 2015. PMID: 25613679
An Orally Available BACE1 Inhibitor That Affords Robust CNS Aβ Reduction without Cardiovascular Liabilities.
Cheng Y, Brown J, Judd TC, Lopez P, Qian W, Powers TS, Chen JJ, Bartberger MD, Chen K, Dunn RT 2nd, Epstein O, Fremeau RT Jr, Harried S, Hickman D, Hitchcock SA, Luo Y, Minatti AE, Patel VF, Vargas HM, Wahl RC, Weiss MM, Wen PH, White RD, Whittington DA, Zheng XM, Wood S. Cheng Y, et al. Among authors: powers ts. ACS Med Chem Lett. 2014 Dec 29;6(2):210-5. doi: 10.1021/ml500458t. eCollection 2015 Feb 12. ACS Med Chem Lett. 2014. PMID: 25699151 Free PMC article.
The design and synthesis of substituted biphenyl libraries.
Pavia MR, Cohen MP, Dilley GJ, Dubuc GR, Durgin TL, Forman FW, Hediger ME, Milot G, Powers TS, Sucholeiki I, Zhou S, Hangauer DG. Pavia MR, et al. Among authors: powers ts. Bioorg Med Chem. 1996 May;4(5):659-66. doi: 10.1016/0968-0896(96)00060-0. Bioorg Med Chem. 1996. PMID: 8804530
A new class of potent matrix metalloproteinase 13 inhibitors for potential treatment of osteoarthritis: Evidence of histologic and clinical efficacy without musculoskeletal toxicity in rat models.
Baragi VM, Becher G, Bendele AM, Biesinger R, Bluhm H, Boer J, Deng H, Dodd R, Essers M, Feuerstein T, Gallagher BM Jr, Gege C, Hochgürtel M, Hofmann M, Jaworski A, Jin L, Kiely A, Korniski B, Kroth H, Nix D, Nolte B, Piecha D, Powers TS, Richter F, Schneider M, Steeneck C, Sucholeiki I, Taveras A, Timmermann A, Van Veldhuizen J, Weik J, Wu X, Xia B. Baragi VM, et al. Among authors: powers ts. Arthritis Rheum. 2009 Jul;60(7):2008-18. doi: 10.1002/art.24629. Arthritis Rheum. 2009. PMID: 19565489 Free article.
Multiple simultaneous synthesis of phenolic libraries.
Meyers HV, Dilley GJ, Durgin TL, Powers TS, Winssinger NA, Zhu H, Pavia MR. Meyers HV, et al. Among authors: powers ts. Mol Divers. 1995 Sep;1(1):13-20. doi: 10.1007/BF01715805. Mol Divers. 1995. PMID: 9237190
Combinatorial Materials Science and Catalysis.
Jandeleit B, Schaefer DJ, Powers TS, Turner HW, Weinberg WH. Jandeleit B, et al. Among authors: powers ts. Angew Chem Int Ed Engl. 1999 Sep;38(17):2494-2532. Angew Chem Int Ed Engl. 1999. PMID: 10508328