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Clinical validation of a next-generation sequencing-based multi-cancer early detection "liquid biopsy" blood test in over 1,000 dogs using an independent testing set: The CANcer Detection in Dogs (CANDiD) study.
Flory A, Kruglyak KM, Tynan JA, McLennan LM, Rafalko JM, Fiaux PC, Hernandez GE, Marass F, Nakashe P, Ruiz-Perez CA, Fath DM, Jennings T, Motalli-Pepio R, Wotrang K, McCleary-Wheeler AL, Lana S, Phillips B, Flesner BK, Leibman NF, LaDue T, Tripp CD, Coomber BL, Woods JP, Miller M, Aiken SW, Wolf-Ringwall A, Borgatti A, Kraska K, Thomson CB, Kosanovich Cahalane A, Murray RL, Kisseberth WC, Camps-Palau MA, Floch F, Beaudu-Lange C, Klajer-Peres A, Keravel O, Fribourg-Blanc LA, Mazetier PC, Marco A, McLeod MB, Portillo E, Clark TS, Judd S, Feinberg CK, Benitez M, Runyan C, Hackett L, Lafey S, Richardson D, Vineyard S, Tefend Campbell M, Dharajiya N, Jensen TJ, van den Boom D, Diaz LA Jr, Grosu DS, Polk A, Marsal K, Hicks SC, Lytle KM, Holtvoigt L, Chibuk J, Chorny I, Tsui DWY. Flory A, et al. Among authors: nakashe p. PLoS One. 2022 Apr 26;17(4):e0266623. doi: 10.1371/journal.pone.0266623. eCollection 2022. PLoS One. 2022. PMID: 35471999 Free PMC article.
Genome-wide Sequencing of Cell-free DNA Enables Detection of Copy-number Alterations in Patients with Cancer Where Tissue Biopsy is Not Feasible.
Jensen TJ, Goodman AM, Ellison CK, Holden KA, Kato S, Kim L, Daniels GA, Fitzgerald K, McCarthy E, Nakashe P, Mazloom AR, Almasri E, McLennan G, Grosu DS, Eisenberg M, Kurzrock R. Jensen TJ, et al. Among authors: nakashe p. Mol Cancer Ther. 2021 Nov;20(11):2274-2279. doi: 10.1158/1535-7163.MCT-20-1066. Epub 2021 Aug 31. Mol Cancer Ther. 2021. PMID: 34465593 Free PMC article.
Genome-Wide Sequencing of Cell-Free DNA Identifies Copy-Number Alterations That Can Be Used for Monitoring Response to Immunotherapy in Cancer Patients.
Jensen TJ, Goodman AM, Kato S, Ellison CK, Daniels GA, Kim L, Nakashe P, McCarthy E, Mazloom AR, McLennan G, Grosu DS, Ehrich M, Kurzrock R. Jensen TJ, et al. Among authors: nakashe p. Mol Cancer Ther. 2019 Feb;18(2):448-458. doi: 10.1158/1535-7163.MCT-18-0535. Epub 2018 Dec 6. Mol Cancer Ther. 2019. PMID: 30523049
Blood-Based Liquid Biopsy for Comprehensive Cancer Genomic Profiling Using Next-Generation Sequencing: An Emerging Paradigm for Non-invasive Cancer Detection and Management in Dogs.
Kruglyak KM, Chibuk J, McLennan L, Nakashe P, Hernandez GE, Motalli-Pepio R, Fath DM, Tynan JA, Holtvoigt LE, Chorny I, Grosu DS, Tsui DWY, Flory A. Kruglyak KM, et al. Among authors: nakashe p. Front Vet Sci. 2021 Jul 8;8:704835. doi: 10.3389/fvets.2021.704835. eCollection 2021. Front Vet Sci. 2021. PMID: 34307538 Free PMC article.
Clinical validation of a blood-based liquid biopsy test integrating cell-free DNA quantification and next-generation sequencing for cancer screening in dogs.
Flory A, Ruiz-Perez CA, Clavere-Graciette AG, Rafalko JM, O'Kell AL, Flesner BK, McLennan LM, Hicks SC, Nakashe P, Phelps-Dunn A, DiMarzio LR, Warren CD, Cohen TA, Chibuk J, Chorny I, Grosu DS, Tsui DWY, Tynan JA, Kruglyak KM. Flory A, et al. Among authors: nakashe p. J Am Vet Med Assoc. 2024 Feb 7;262(5):665-673. doi: 10.2460/javma.23.10.0564. Print 2024 May 1. J Am Vet Med Assoc. 2024. PMID: 38324993