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Diabetes is Associated with Higher Trimethylamine N-oxide Plasma Levels.
Dambrova M, Latkovskis G, Kuka J, Strele I, Konrade I, Grinberga S, Hartmane D, Pugovics O, Erglis A, Liepinsh E. Dambrova M, et al. Among authors: pugovics o. Exp Clin Endocrinol Diabetes. 2016 Apr;124(4):251-6. doi: 10.1055/s-0035-1569330. Epub 2016 Apr 28. Exp Clin Endocrinol Diabetes. 2016. PMID: 27123785
Inhibition of L-carnitine biosynthesis and transport by methyl-γ-butyrobetaine decreases fatty acid oxidation and protects against myocardial infarction.
Liepinsh E, Makrecka-Kuka M, Kuka J, Vilskersts R, Makarova E, Cirule H, Loza E, Lola D, Grinberga S, Pugovics O, Kalvins I, Dambrova M. Liepinsh E, et al. Among authors: pugovics o. Br J Pharmacol. 2015 Mar;172(5):1319-32. doi: 10.1111/bph.13004. Epub 2015 Jan 12. Br J Pharmacol. 2015. PMID: 25363063 Free PMC article.
Effects of long-term mildronate treatment on cardiac and liver functions in rats.
Liepinsh E, Kuka J, Svalbe B, Vilskersts R, Skapare E, Cirule H, Pugovics O, Kalvinsh I, Dambrova M. Liepinsh E, et al. Among authors: pugovics o. Basic Clin Pharmacol Toxicol. 2009 Dec;105(6):387-94. doi: 10.1111/j.1742-7843.2009.00461.x. Epub 2009 Aug 5. Basic Clin Pharmacol Toxicol. 2009. PMID: 19663820 Free article.
Selective inhibition of OCTN2 is more effective than inhibition of gamma-butyrobetaine dioxygenase to decrease the availability of l-carnitine and to reduce myocardial infarct size.
Liepinsh E, Makrecka M, Kuka J, Cirule H, Makarova E, Sevostjanovs E, Grinberga S, Vilskersts R, Lola D, Loza E, Stonans I, Pugovics O, Dambrova M. Liepinsh E, et al. Among authors: pugovics o. Pharmacol Res. 2014 Jul;85:33-8. doi: 10.1016/j.phrs.2014.05.002. Epub 2014 May 14. Pharmacol Res. 2014. PMID: 24836867
32 results