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Dry and liquid formulations of IBT-V02, a novel multi-component toxoid vaccine, are effective against Staphylococcus aureus isolates from low-to-middle income countries.
Wang Y, Mukherjee I, Venkatasubramaniam A, Dikeman D, Orlando N, Zhang J, Ortines R, Mednikov M, Sherchand SP, Kanipakala T, Le T, Shukla S, Ketner M, Adhikari RP, Karauzum H, Aman MJ, Archer NK. Wang Y, et al. Front Immunol. 2024 Apr 3;15:1373367. doi: 10.3389/fimmu.2024.1373367. eCollection 2024. Front Immunol. 2024. PMID: 38633244 Free PMC article.
Staphylococcus aureus proteases trigger eosinophil-mediated skin inflammation.
Kline SN, Orlando NA, Lee AJ, Wu MJ, Zhang J, Youn C, Feller LE, Pontaza C, Dikeman D, Limjunyawong N, Williams KL, Wang Y, Cihakova D, Jacobsen EA, Durum SK, Garza LA, Dong X, Archer NK. Kline SN, et al. Proc Natl Acad Sci U S A. 2024 Feb 6;121(6):e2309243121. doi: 10.1073/pnas.2309243121. Epub 2024 Jan 30. Proc Natl Acad Sci U S A. 2024. PMID: 38289950
A novel rodent model of chronic spinal implant-associated infection.
DeMourdant T, Rajkovic CJ, Tracz JA, Perdomo-Pantoja A, Judy BF, Hernandez VN, Lin J, Lazzari JL, Dikeman DA, Archer NK, Davis KM, Gordon O, Witham TF. DeMourdant T, et al. Spine J. 2023 Sep;23(9):1389-1399. doi: 10.1016/j.spinee.2023.05.014. Epub 2023 May 27. Spine J. 2023. PMID: 37247639
Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection.
Dong X, Limjunyawong N, Sypek EI, Wang G, Ortines RV, Youn C, Alphonse MP, Dikeman D, Wang Y, Lay M, Kothari R, Vasavda C, Pundir P, Goff L, Miller LS, Lu W, Garza LA, Kim BS, Archer NK, Dong X. Dong X, et al. Immunity. 2022 Sep 13;55(9):1645-1662.e7. doi: 10.1016/j.immuni.2022.06.021. Epub 2022 Jul 25. Immunity. 2022. PMID: 35882236 Free PMC article.