R01 CA204345/CA/NCI NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2016	2
2017	5
2018	14
2019	3
2020	9
2021	2
2022	13
2023	1
2024	0

1

Difluoromethylornithine rebalances aberrant polyamine ratios in Snyder-Robinson syndrome.

Stewart TM, Foley JR, Holbert CE, Khomutov M, Rastkari N, Tao X, Khomutov AR, Zhai RG, Casero RA Jr. Stewart TM, et al. EMBO Mol Med. 2023 Nov 8;15(11):e17833. doi: 10.15252/emmm.202317833. Epub 2023 Sep 13. EMBO Mol Med. 2023. PMID: 37702369 Free PMC article.

2

Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout.

Steimbach RR, Herbst-Gervasoni CJ, Lechner S, Stewart TM, Klinke G, Ridinger J, Géraldy MNE, Tihanyi G, Foley JR, Uhrig U, Kuster B, Poschet G, Casero RA Jr, Médard G, Oehme I, Christianson DW, Gunkel N, Miller AK. Steimbach RR, et al. J Am Chem Soc. 2022 Oct 19;144(41):18861-18875. doi: 10.1021/jacs.2c05030. Epub 2022 Oct 6. J Am Chem Soc. 2022. PMID: 36200994 Free PMC article.

3

Renal Transcriptome and Metabolome in Mice with Principal Cell-Specific Ablation of the Tsc1 Gene: Derangements in Pathways Associated with Cell Metabolism, Growth and Acid Secretion.

Zahedi K, Barone S, Brooks M, Murray Stewart T, Casero RA Jr, Soleimani M. Zahedi K, et al. Int J Mol Sci. 2022 Sep 13;23(18):10601. doi: 10.3390/ijms231810601. Int J Mol Sci. 2022. PMID: 36142537 Free PMC article.

4

Identification and Characterization of Novel Small-Molecule SMOX Inhibitors.

Furbish AB, Alford AS, Burger P, Peterson YK, Murray-Stewart T, Casero RA Jr, Woster PM. Furbish AB, et al. Med Sci (Basel). 2022 Aug 30;10(3):47. doi: 10.3390/medsci10030047. Med Sci (Basel). 2022. PMID: 36135832 Free PMC article.

5

Interrogation of T Cell-Enriched Tumors Reveals Prognostic and Immunotherapeutic Implications of Polyamine Metabolism.

Harbison RA, Pandey R, Considine M, Leone RD, Murray-Stewart T, Erbe R, Mandal R, Burns M, Casero RA Jr, Seiwert T, Fakhry C, Pardoll D, Fertig E, Powell JD. Harbison RA, et al. Cancer Res Commun. 2022 Jul;2(7):639-652. doi: 10.1158/2767-9764.crc-22-0061. Epub 2022 Jul 13. Cancer Res Commun. 2022. PMID: 36052016 Free PMC article.

6

Polyamine-Based Nanostructures Share Polyamine Transport Mechanisms with Native Polyamines and Their Analogues: Significance for Polyamine-Targeted Therapy.

Holbert CE, Foley JR, Yu A, Murray Stewart T, Phanstiel O 4th, Oupicky D, Casero RA Jr. Holbert CE, et al. Med Sci (Basel). 2022 Aug 22;10(3):44. doi: 10.3390/medsci10030044. Med Sci (Basel). 2022. PMID: 35997336 Free PMC article.

7

Histone deacetylase-10 liberates spermidine to support polyamine homeostasis and tumor cell growth.

Stewart TM, Foley JR, Holbert CE, Klinke G, Poschet G, Steimbach RR, Miller AK, Casero RA Jr. Stewart TM, et al. J Biol Chem. 2022 Oct;298(10):102407. doi: 10.1016/j.jbc.2022.102407. Epub 2022 Aug 19. J Biol Chem. 2022. PMID: 35988653 Free PMC article.

8

Helping the helpers: polyamines help maintain helper T-cell lineage fidelity.

Stewart TM, Holbert CE, Casero RA Jr. Stewart TM, et al. Immunometabolism (Cobham). 2022 Aug 5;4(3):e00002. doi: 10.1097/IN9.0000000000000002. eCollection 2022 Jul. Immunometabolism (Cobham). 2022. PMID: 35966633 Free PMC article.

9

Hyaluronate-coated perfluoroalkyl polyamine prodrugs as bioactive siRNA delivery systems for the treatment of peritoneal cancers.

Yu A, Tang S, Ding L, Foley J, Tang W, Jia H, Panja S, Holbert CE, Hang Y, Stewart TM, Smith LM, Sil D, Casero RA Jr, Oupický D. Yu A, et al. Biomater Adv. 2022 May;136:212755. doi: 10.1016/j.bioadv.2022.212755. Epub 2022 Mar 17. Biomater Adv. 2022. PMID: 35813988 Free PMC article.

10

Phenylbutyrate modulates polyamine acetylase and ameliorates Snyder-Robinson syndrome in a Drosophila model and patient cells.

Tao X, Zhu Y, Diaz-Perez Z, Yu SH, Foley JR, Stewart TM, Casero RA Jr, Steet R, Zhai RG. Tao X, et al. JCI Insight. 2022 Jul 8;7(13):e158457. doi: 10.1172/jci.insight.158457. JCI Insight. 2022. PMID: 35801587 Free PMC article.

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