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Gasdermin D permeabilization of mitochondrial inner and outer membranes accelerates and enhances pyroptosis.
Miao R, Jiang C, Chang WY, Zhang H, An J, Ho F, Chen P, Zhang H, Junqueira C, Amgalan D, Liang FG, Zhang J, Evavold CL, Hafner-Bratkovič I, Zhang Z, Fontana P, Xia S, Waldeck-Weiermair M, Pan Y, Michel T, Bar-Peled L, Wu H, Kagan JC, Kitsis RN, Zhang P, Liu X, Lieberman J. Miao R, et al. Immunity. 2023 Nov 14;56(11):2523-2541.e8. doi: 10.1016/j.immuni.2023.10.004. Epub 2023 Nov 3. Immunity. 2023. PMID: 37924812
Disulfiram blocks inflammatory TLR4 signaling by targeting MD-2.
Bai Y, Min R, Chen P, Mei S, Deng F, Zheng Z, Jiang C, Miao R, Wu Z, Zhang P, Pan Y, Lieberman J, Liu X. Bai Y, et al. Proc Natl Acad Sci U S A. 2023 Aug;120(31):e2306399120. doi: 10.1073/pnas.2306399120. Epub 2023 Jul 24. Proc Natl Acad Sci U S A. 2023. PMID: 37487070 Free PMC article.
Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration.
Neel DV, Basu H, Gunner G, Bergstresser MD, Giadone RM, Chung H, Miao R, Chou V, Brody E, Jiang X, Lee E, Watts ME, Marques C, Held A, Wainger B, Lagier-Tourenne C, Zhang YJ, Petrucelli L, Young-Pearse TL, Chen-Plotkin AS, Rubin LL, Lieberman J, Chiu IM. Neel DV, et al. Neuron. 2023 Apr 19;111(8):1222-1240.e9. doi: 10.1016/j.neuron.2023.02.019. Epub 2023 Mar 13. Neuron. 2023. PMID: 36917977 Free PMC article.
Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis.
Deng W, Bai Y, Deng F, Pan Y, Mei S, Zheng Z, Min R, Wu Z, Li W, Miao R, Zhang Z, Kupper TS, Lieberman J, Liu X. Deng W, et al. Nature. 2022 Feb;602(7897):496-502. doi: 10.1038/s41586-021-04384-4. Epub 2022 Feb 2. Nature. 2022. PMID: 35110732 Free PMC article.
Channelling inflammation: gasdermins in physiology and disease.
Liu X, Xia S, Zhang Z, Wu H, Lieberman J. Liu X, et al. Nat Rev Drug Discov. 2021 May;20(5):384-405. doi: 10.1038/s41573-021-00154-z. Epub 2021 Mar 10. Nat Rev Drug Discov. 2021. PMID: 33692549 Free PMC article. Review.
12 results