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Covalent Degrader of the Oncogenic Transcription Factor β-Catenin.
Gowans FA, Forte N, Hatcher J, Huang OW, Wang Y, Poblano BEA, Wertz IE, Nomura DK. Gowans FA, et al. bioRxiv [Preprint]. 2023 Nov 2:2023.10.31.565018. doi: 10.1101/2023.10.31.565018. bioRxiv. 2023. PMID: 37961622 Free PMC article. Preprint.
Rational Chemical Design of Molecular Glue Degraders.
Toriki ES, Papatzimas JW, Nishikawa K, Dovala D, Frank AO, Hesse MJ, Dankova D, Song JG, Bruce-Smythe M, Struble H, Garcia FJ, Brittain SM, Kile AC, McGregor LM, McKenna JM, Tallarico JA, Schirle M, Nomura DK. Toriki ES, et al. ACS Cent Sci. 2023 Apr 11;9(5):915-926. doi: 10.1021/acscentsci.2c01317. eCollection 2023 May 24. ACS Cent Sci. 2023. PMID: 37252349 Free PMC article.
Targeted Protein Degradation through E2 Recruitment.
Forte N, Dovala D, Hesse MJ, McKenna JM, Tallarico JA, Schirle M, Nomura DK. Forte N, et al. ACS Chem Biol. 2023 Apr 21;18(4):897-904. doi: 10.1021/acschembio.3c00040. Epub 2023 Mar 20. ACS Chem Biol. 2023. PMID: 36940189 Free PMC article.
Advances in covalent drug discovery.
Boike L, Henning NJ, Nomura DK. Boike L, et al. Nat Rev Drug Discov. 2022 Dec;21(12):881-898. doi: 10.1038/s41573-022-00542-z. Epub 2022 Aug 25. Nat Rev Drug Discov. 2022. PMID: 36008483 Free PMC article. Review.
Deubiquitinase-targeting chimeras for targeted protein stabilization.
Henning NJ, Boike L, Spradlin JN, Ward CC, Liu G, Zhang E, Belcher BP, Brittain SM, Hesse MJ, Dovala D, McGregor LM, Valdez Misiolek R, Plasschaert LW, Rowlands DJ, Wang F, Frank AO, Fuller D, Estes AR, Randal KL, Panidapu A, McKenna JM, Tallarico JA, Schirle M, Nomura DK. Henning NJ, et al. Nat Chem Biol. 2022 Apr;18(4):412-421. doi: 10.1038/s41589-022-00971-2. Epub 2022 Feb 24. Nat Chem Biol. 2022. PMID: 35210618 Free PMC article.
19 results