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Page 1
The prostaglandin E2 EP3 receptor has disparate effects on islet insulin secretion and content in β-cells in a high-fat diet-induced mouse model of obesity.
Neuman JC, Reuter A, Carbajal KA, Schaid MD, Kelly G, Connors K, Kaiser C, Krause J, Hurley LD, Olvera A, Davis DB, Wisinski JA, Gannon M, Kimple ME. Neuman JC, et al. Am J Physiol Endocrinol Metab. 2024 May 1;326(5):E567-E576. doi: 10.1152/ajpendo.00061.2023. Epub 2024 Mar 13. Am J Physiol Endocrinol Metab. 2024. PMID: 38477664
What the BTBR/J mouse has taught us about diabetes and diabetic complications.
Keller MP, Hudkins KL, Shalev A, Bhatnagar S, Kebede MA, Merrins MJ, Davis DB, Alpers CE, Kimple ME, Attie AD. Keller MP, et al. iScience. 2023 Jun 7;26(7):107036. doi: 10.1016/j.isci.2023.107036. eCollection 2023 Jul 21. iScience. 2023. PMID: 37360692 Free PMC article. Review.
Metformin Monotherapy Alters the Human Plasma Lipidome Independent of Clinical Markers of Glycemic Control and Cardiovascular Disease Risk in a Type 2 Diabetes Clinical Cohort.
Wancewicz B, Zhu Y, Fenske RJ, Weeks AM, Wenger K, Pabich S, Daniels M, Punt M, Nall R, Peter DC, Brasier A, Cox ED, Davis DB, Ge Y, Kimple ME. Wancewicz B, et al. J Pharmacol Exp Ther. 2023 Aug;386(2):169-180. doi: 10.1124/jpet.122.001493. Epub 2023 Mar 14. J Pharmacol Exp Ther. 2023. PMID: 36918276 Free PMC article.
Pharmacological blockade of the EP3 prostaglandin E2 receptor in the setting of type 2 diabetes enhances β-cell proliferation and identity and relieves oxidative damage.
Bosma KJ, Andrei SR, Katz LS, Smith AA, Dunn JC, Ricciardi VF, Ramirez MA, Baumel-Alterzon S, Pace WA, Carroll DT, Overway EM, Wolf EM, Kimple ME, Sheng Q, Scott DK, Breyer RM, Gannon M. Bosma KJ, et al. Mol Metab. 2021 Dec;54:101347. doi: 10.1016/j.molmet.2021.101347. Epub 2021 Oct 6. Mol Metab. 2021. PMID: 34626853 Free PMC article.
Human Islet Expression Levels of Prostaglandin E2 Synthetic Enzymes, But Not Prostaglandin EP3 Receptor, Are Positively Correlated with Markers of β-Cell Function and Mass in Nondiabetic Obesity.
Truchan NA, Fenske RJ, Sandhu HK, Weeks AM, Patibandla C, Wancewicz B, Pabich S, Reuter A, Harrington JM, Brill AL, Peter DC, Nall R, Daniels M, Punt M, Kaiser CE, Cox ED, Ge Y, Davis DB, Kimple ME. Truchan NA, et al. ACS Pharmacol Transl Sci. 2021 Jun 16;4(4):1338-1348. doi: 10.1021/acsptsci.1c00045. eCollection 2021 Aug 13. ACS Pharmacol Transl Sci. 2021. PMID: 34423270 Free PMC article.
The influence of intermittent hypoxia, obesity, and diabetes on male genitourinary anatomy and voiding physiology.
Abler LL, O'Driscoll CA, Colopy SA, Stietz KPK, Wang P, Wang Z, Hartmann F, Crader-Smith SM, Oellete JN, Mehta V, Oakes SR, Grimes MD, Mitchell GS, Baan M, Gallagher SJ, Davis DB, Kimple ME, Bjorling DE, Watters JJ, Vezina CM. Abler LL, et al. Am J Physiol Renal Physiol. 2021 Jul 1;321(1):F82-F92. doi: 10.1152/ajprenal.00112.2021. Epub 2021 Jun 14. Am J Physiol Renal Physiol. 2021. PMID: 34121451 Free PMC article.
37 results