R01 GM047251/GM/NIGMS NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
1997	1
1998	1
2003	1
2008	3
2009	2
2010	2
2011	3
2012	2
2013	1
2014	1
2015	1
2016	2
2017	1
2018	2
2019	1
2020	4
2021	2
2022	1
2023	4
2024	1

1

Mammalian DNA ligases; roles in maintaining genome integrity.

Sallmyr A, Bhandari SK, Naila T, Tomkinson AE. Sallmyr A, et al. J Mol Biol. 2024 Jan 1;436(1):168276. doi: 10.1016/j.jmb.2023.168276. Epub 2023 Sep 13. J Mol Biol. 2024. PMID: 37714297 Review.

2

DNA-PK is activated by SIRT2 deacetylation to promote DNA double-strand break repair by non-homologous end joining.

Head PE, Kapoor-Vazirani P, Nagaraju GP, Zhang H, Rath SK, Luong NC, Haji-Seyed-Javadi R, Sesay F, Wang SY, Duong DM, Daddacha W, Minten EV, Song B, Danelia D, Liu X, Li S, Ortlund EA, Seyfried NT, Smalley DM, Wang Y, Deng X, Dynan WS, El-Rayes B, Davis AJ, Yu DS. Head PE, et al. Nucleic Acids Res. 2023 Aug 25;51(15):7972-7987. doi: 10.1093/nar/gkad549. Nucleic Acids Res. 2023. PMID: 37395399 Free PMC article.

3

ATM phosphorylates the FATC domain of DNA-PKcs at threonine 4102 to promote non-homologous end joining.

Lu H, Zhang Q, Laverty DJ, Puncheon AC, Augustine MM, Williams GJ, Nagel ZD, Chen BPC, Davis AJ. Lu H, et al. Nucleic Acids Res. 2023 Jul 21;51(13):6770-6783. doi: 10.1093/nar/gkad505. Nucleic Acids Res. 2023. PMID: 37309889 Free PMC article.

4

Cryo-EM visualization of DNA-PKcs structural intermediates in NHEJ.

Chen S, Vogt A, Lee L, Naila T, McKeown R, Tomkinson AE, Lees-Miller SP, He Y. Chen S, et al. Sci Adv. 2023 Jun 2;9(22):eadg2838. doi: 10.1126/sciadv.adg2838. Epub 2023 May 31. Sci Adv. 2023. PMID: 37256947 Free PMC article.

5

Restoration of DNA repair mitigates genome instability and increases productivity of Chinese hamster ovary cells.

Spahn PN, Zhang X, Hu Q, Lu H, Hamaker NK, Hefzi H, Li S, Kuo CC, Huang Y, Lee JC, Davis AJ, Ly P, Lee KH, Lewis NE. Spahn PN, et al. Biotechnol Bioeng. 2022 Mar;119(3):963-982. doi: 10.1002/bit.28016. Epub 2022 Jan 5. Biotechnol Bioeng. 2022. PMID: 34953085 Free PMC article.

6

Structural basis of long-range to short-range synaptic transition in NHEJ.

Chen S, Lee L, Naila T, Fishbain S, Wang A, Tomkinson AE, Lees-Miller SP, He Y. Chen S, et al. Nature. 2021 May;593(7858):294-298. doi: 10.1038/s41586-021-03458-7. Epub 2021 Apr 14. Nature. 2021. PMID: 33854234 Free PMC article.

7

MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway.

Guan J, Lu C, Jin Q, Lu H, Chen X, Tian L, Zhang Y, Ortega J, Zhang J, Siteni S, Chen M, Gu L, Shay JW, Davis AJ, Chen ZJ, Fu YX, Li GM. Guan J, et al. Cancer Cell. 2021 Jan 11;39(1):109-121.e5. doi: 10.1016/j.ccell.2020.11.004. Epub 2020 Dec 17. Cancer Cell. 2021. PMID: 33338427 Free PMC article.

8

NAD+ is not utilized as a co-factor for DNA ligation by human DNA ligase IV.

Zhao B, Naila T, Lieber MR, Tomkinson AE. Zhao B, et al. Nucleic Acids Res. 2020 Dec 16;48(22):12746-12750. doi: 10.1093/nar/gkaa1118. Nucleic Acids Res. 2020. PMID: 33264406 Free PMC article.

9

Human DNA ligases in replication and repair.

Sallmyr A, Rashid I, Bhandari SK, Naila T, Tomkinson AE. Sallmyr A, et al. DNA Repair (Amst). 2020 Sep;93:102908. doi: 10.1016/j.dnarep.2020.102908. DNA Repair (Amst). 2020. PMID: 33087274 Free PMC article. Review.

10

Altered DNA ligase activity in human disease.

Tomkinson AE, Naila T, Khattri Bhandari S. Tomkinson AE, et al. Mutagenesis. 2020 Feb 13;35(1):51-60. doi: 10.1093/mutage/gez026. Mutagenesis. 2020. PMID: 31630206 Free PMC article. Review.

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