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The rat kidney contains high levels of prouroguanylin (the uroguanylin precursor) but does not express GC-C (the enteric uroguanylin receptor).
Am J Physiol Renal Physiol. 2011 Feb;300(2):F561-73. doi: 10.1152/ajprenal.00282.2010. Epub 2010 Nov 24.
Am J Physiol Renal Physiol. 2011.
PMID: 21106860
Free PMC article.
The natriuretic peptide uroguanylin elicits physiologic actions through 2 distinct topoisomers.
Moss NG, Riguera DA, Solinga RM, Kessler MM, Zimmer DP, Arendshorst WJ, Currie MG, Goy MF.
Moss NG, et al.
Hypertension. 2009 May;53(5):867-76. doi: 10.1161/HYPERTENSIONAHA.108.128264. Epub 2009 Mar 16.
Hypertension. 2009.
PMID: 19289652
Free PMC article.
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Circulating prouroguanylin is processed to its active natriuretic form exclusively within the renal tubules.
Qian X, Moss NG, Fellner RC, Goy MF.
Qian X, et al.
Endocrinology. 2008 Sep;149(9):4499-509. doi: 10.1210/en.2007-1724. Epub 2008 May 22.
Endocrinology. 2008.
PMID: 18499761
Free PMC article.
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Uroguanylin, an intestinal natriuretic peptide, is delivered to the kidney as an unprocessed propeptide.
Moss NG, Fellner RC, Qian X, Yu SJ, Li Z, Nakazato M, Goy MF.
Moss NG, et al.
Endocrinology. 2008 Sep;149(9):4486-98. doi: 10.1210/en.2007-1725. Epub 2008 May 22.
Endocrinology. 2008.
PMID: 18499760
Free PMC article.
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