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Mechanically activated ion channel PIEZO1 is required for lymphatic valve formation.
Nonomura K, Lukacs V, Sweet DT, Goddard LM, Kanie A, Whitwam T, Ranade SS, Fujimori T, Kahn ML, Patapoutian A. Nonomura K, et al. Proc Natl Acad Sci U S A. 2018 Dec 11;115(50):12817-12822. doi: 10.1073/pnas.1817070115. Epub 2018 Nov 27. Proc Natl Acad Sci U S A. 2018. PMID: 30482854 Free PMC article.
HA-ving lymphatics improves lung transplantation.
Maltzman JS, Reed HO, Kahn ML. Maltzman JS, et al. J Clin Invest. 2015 Nov 2;125(11):3999-4001. doi: 10.1172/JCI84549. Epub 2015 Oct 20. J Clin Invest. 2015. PMID: 26524589 Free PMC article.
Lymphatic function is required prenatally for lung inflation at birth.
Jakus Z, Gleghorn JP, Enis DR, Sen A, Chia S, Liu X, Rawnsley DR, Yang Y, Hess PR, Zou Z, Yang J, Guttentag SH, Nelson CM, Kahn ML. Jakus Z, et al. J Exp Med. 2014 May 5;211(5):815-26. doi: 10.1084/jem.20132308. Epub 2014 Apr 14. J Exp Med. 2014. PMID: 24733830 Free PMC article.