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Constitutive activity at the cannabinoid CB1 receptor is required for behavioral response to noxious chemical stimulation of TRPV1: antinociceptive actions of CB1 inverse agonists.
Fioravanti B, De Felice M, Stucky CL, Medler KA, Luo MC, Gardell LR, Ibrahim M, Malan TP Jr, Yamamura HI, Ossipov MH, King T, Lai J, Porreca F, Vanderah TW. Fioravanti B, et al. J Neurosci. 2008 Nov 5;28(45):11593-602. doi: 10.1523/JNEUROSCI.3322-08.2008. J Neurosci. 2008. PMID: 18987195 Free PMC article.