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Eicosanoyl-5-hydroxytryptamide (EHT) prevents Alzheimer's disease-related cognitive and electrophysiological impairments in mice exposed to elevated concentrations of oligomeric beta-amyloid.
Asam K, Staniszewski A, Zhang H, Melideo SL, Mazzeo A, Voronkov M, Huber KL, Pérez E, Stock M, Stock JB, Arancio O, Nicholls RE. Asam K, et al. PLoS One. 2017 Dec 18;12(12):e0189413. doi: 10.1371/journal.pone.0189413. eCollection 2017. PLoS One. 2017. PMID: 29253878 Free PMC article.
Amyloid-β Peptide Is Needed for cGMP-Induced Long-Term Potentiation and Memory.
Palmeri A, Ricciarelli R, Gulisano W, Rivera D, Rebosio C, Calcagno E, Tropea MR, Conti S, Das U, Roy S, Pronzato MA, Arancio O, Fedele E, Puzzo D. Palmeri A, et al. J Neurosci. 2017 Jul 19;37(29):6926-6937. doi: 10.1523/JNEUROSCI.3607-16.2017. Epub 2017 Jun 16. J Neurosci. 2017. PMID: 28626017 Free PMC article.
PP2A methylation controls sensitivity and resistance to β-amyloid-induced cognitive and electrophysiological impairments.
Nicholls RE, Sontag JM, Zhang H, Staniszewski A, Yan S, Kim CY, Yim M, Woodruff CM, Arning E, Wasek B, Yin D, Bottiglieri T, Sontag E, Kandel ER, Arancio O. Nicholls RE, et al. Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):3347-52. doi: 10.1073/pnas.1521018113. Epub 2016 Mar 7. Proc Natl Acad Sci U S A. 2016. PMID: 26951658 Free PMC article.