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(S)-4-Amino-5-phenoxypentanoate designed as a potential selective agonist of the bacterial transcription factor GabR.
Protein Sci. 2020 Aug;29(8):1816-1828. doi: 10.1002/pro.3905. Epub 2020 Jul 17.
Protein Sci. 2020.
PMID: 32557944
Free PMC article.
Selective Targeting by a Mechanism-Based Inactivator against Pyridoxal 5'-Phosphate-Dependent Enzymes: Mechanisms of Inactivation and Alternative Turnover.
Mascarenhas R, Le HV, Clevenger KD, Lehrer HJ, Ringe D, Kelleher NL, Silverman RB, Liu D.
Mascarenhas R, et al.
Biochemistry. 2017 Sep 19;56(37):4951-4961. doi: 10.1021/acs.biochem.7b00499. Epub 2017 Sep 6.
Biochemistry. 2017.
PMID: 28816437
Free PMC article.
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PLP and GABA trigger GabR-mediated transcription regulation in Bacillus subtilis via external aldimine formation.
Wu R, Sanishvili R, Belitsky BR, Juncosa JI, Le HV, Lehrer HJ, Farley M, Silverman RB, Petsko GA, Ringe D, Liu D.
Wu R, et al.
Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):3891-3896. doi: 10.1073/pnas.1703019114. Epub 2017 Mar 27.
Proc Natl Acad Sci U S A. 2017.
PMID: 28348215
Free PMC article.
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Binding of transcription factor GabR to DNA requires recognition of DNA shape at a location distinct from its cognate binding site.
Al-Zyoud WA, Hynson RM, Ganuelas LA, Coster AC, Duff AP, Baker MA, Stewart AG, Giannoulatou E, Ho JW, Gaus K, Liu D, Lee LK, Böcking T.
Al-Zyoud WA, et al.
Nucleic Acids Res. 2016 Feb 18;44(3):1411-20. doi: 10.1093/nar/gkv1466. Epub 2015 Dec 17.
Nucleic Acids Res. 2016.
PMID: 26681693
Free PMC article.
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