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2013 1
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Page 1
Mitochondrial ATP fuels ABC transporter-mediated drug efflux in cancer chemoresistance.
Giddings EL, Champagne DP, Wu MH, Laffin JM, Thornton TM, Valenca-Pereira F, Culp-Hill R, Fortner KA, Romero N, East J, Cao P, Arias-Pulido H, Sidhu KS, Silverstrim B, Kam Y, Kelley S, Pereira M, Bates SE, Bunn JY, Fiering SN, Matthews DE, Robey RW, Stich D, D'Alessandro A, Rincon M. Giddings EL, et al. Nat Commun. 2021 May 14;12(1):2804. doi: 10.1038/s41467-021-23071-6. Nat Commun. 2021. PMID: 33990571 Free PMC article.
The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury.
Barbier-Torres L, Iruzubieta P, Fernández-Ramos D, Delgado TC, Taibo D, Guitiérrez-de-Juan V, Varela-Rey M, Azkargorta M, Navasa N, Fernández-Tussy P, Zubiete-Franco I, Simon J, Lopitz-Otsoa F, Lachiondo-Ortega S, Crespo J, Masson S, McCain MV, Villa E, Reeves H, Elortza F, Lucena MI, Hernández-Alvarez MI, Zorzano A, Andrade RJ, Lu SC, Mato JM, Anguita J, Rincón M, Martínez-Chantar ML. Barbier-Torres L, et al. Nat Commun. 2017 Dec 12;8(1):2068. doi: 10.1038/s41467-017-01970-x. Nat Commun. 2017. PMID: 29233977 Free PMC article.
Deficiency of mitochondrial modulator MCJ promotes chemoresistance in breast cancer.
Fernández-Cabezudo MJ, Faour I, Jones K, Champagne DP, Jaloudi MA, Mohamed YA, Bashir G, Almarzooqi S, Albawardi A, Hashim MJ, Roberts TS, El-Salhat H, El-Taji H, Kassis A, O'Sullivan DE, Christensen BC, DeGregori J, Al-Ramadi BK, Rincon M. Fernández-Cabezudo MJ, et al. JCI Insight. 2016 May 19;1(7):e86873. doi: 10.1172/jci.insight.86873. JCI Insight. 2016. PMID: 27275014 Free PMC article.
Regulation of oxidative stress by methylation-controlled J protein controls macrophage responses to inflammatory insults.
Navasa N, Martín I, Iglesias-Pedraz JM, Beraza N, Atondo E, Izadi H, Ayaz F, Fernández-Álvarez S, Hatle K, Som A, Dienz O, Osborne BA, Martínez-Chantar ML, Rincón M, Anguita J. Navasa N, et al. J Infect Dis. 2015 Jan 1;211(1):135-45. doi: 10.1093/infdis/jiu389. Epub 2014 Jul 14. J Infect Dis. 2015. PMID: 25028693 Free PMC article.