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Expression of inducible factors reprograms CAR-T cells for enhanced function and safety.
Smole A, Benton A, Poussin MA, Eiva MA, Mezzanotte C, Camisa B, Greco B, Sharma P, Minutolo NG, Gray F, Bear AS, Baroja ML, Cummins C, Xu C, Sanvito F, Goldgewicht AL, Blanchard T, Rodriguez-Garcia A, Klichinsky M, Bonini C, June CH, Posey AD Jr, Linette GP, Carreno BM, Casucci M, Powell DJ Jr. Smole A, et al. Cancer Cell. 2022 Dec 12;40(12):1470-1487.e7. doi: 10.1016/j.ccell.2022.11.006. Cancer Cell. 2022. PMID: 36513049 Free PMC article.
Novel phosphatidylserine-binding molecule enhances antitumor T-cell responses by targeting immunosuppressive exosomes in human tumor microenvironments.
Bhatta M, Shenoy GN, Loyall JL, Gray BD, Bapardekar M, Conway A, Minderman H, Kelleher RJ Jr, Carreno BM, Linette G, Shultz LD, Odunsi K, Balu-Iyer SV, Pak KY, Bankert RB. Bhatta M, et al. J Immunother Cancer. 2021 Oct;9(10):e003148. doi: 10.1136/jitc-2021-003148. J Immunother Cancer. 2021. PMID: 34599030 Free PMC article.
Immunological ignorance is an enabling feature of the oligo-clonal T cell response to melanoma neoantigens.
Linette GP, Becker-Hapak M, Skidmore ZL, Baroja ML, Xu C, Hundal J, Spencer DH, Fu W, Cummins C, Robnett M, Kaabinejadian S, Hildebrand WH, Magrini V, Demeter R, Krupnick AS, Griffith OL, Griffith M, Mardis ER, Carreno BM. Linette GP, et al. Proc Natl Acad Sci U S A. 2019 Nov 19;116(47):23662-23670. doi: 10.1073/pnas.1906026116. Epub 2019 Nov 4. Proc Natl Acad Sci U S A. 2019. PMID: 31685621 Free PMC article.
Neoantigen Vaccines Pass the Immunogenicity Test.
Linette GP, Carreno BM. Linette GP, et al. Trends Mol Med. 2017 Oct;23(10):869-871. doi: 10.1016/j.molmed.2017.08.007. Epub 2017 Aug 31. Trends Mol Med. 2017. PMID: 28867556 Free PMC article.