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Year Number of Results
2019 6
2020 14
2021 16
2022 11
2023 12
2024 1

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56 results

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Page 1
Effects of aging on glucose and lipid metabolism in mice.
Lien EC, Vu N, Westermark AM, Danai LV, Lau AN, Gültekin Y, Kukurugya MA, Bennett BD, Vander Heiden MG. Lien EC, et al. bioRxiv [Preprint]. 2023 Dec 18:2023.12.17.572088. doi: 10.1101/2023.12.17.572088. bioRxiv. 2023. PMID: 38187759 Free PMC article. Preprint.
Metabolite profiling of human renal cell carcinoma reveals tissue-origin dominance in nutrient availability.
Abbott KL, Ali A, Reinfeld BI, Deik A, Subudhi S, Landis MD, Hongo RA, Young KL, Kunchok T, Nabel CS, Crowder KD, Kent JR, Madariaga MLL, Jain RK, Beckermann KE, Lewis CA, Clish CB, Muir A, Rathmell WK, Rathmell JC, Vander Heiden MG. Abbott KL, et al. bioRxiv [Preprint]. 2024 Apr 8:2023.12.24.573250. doi: 10.1101/2023.12.24.573250. bioRxiv. 2024. PMID: 38187626 Free PMC article. Preprint.
Manipulating mitochondrial electron flow enhances tumor immunogenicity.
Mangalhara KC, Varanasi SK, Johnson MA, Burns MJ, Rojas GR, Esparza Moltó PB, Sainz AG, Tadepalle N, Abbott KL, Mendiratta G, Chen D, Farsakoglu Y, Kunchok T, Hoffmann FA, Parisi B, Rincon M, Vander Heiden MG, Bosenberg M, Hargreaves DC, Kaech SM, Shadel GS. Mangalhara KC, et al. Science. 2023 Sep 22;381(6664):1316-1323. doi: 10.1126/science.abq1053. Epub 2023 Sep 21. Science. 2023. PMID: 37733872 Free PMC article.
Screening in serum-derived medium reveals differential response to compounds targeting metabolism.
Abbott KL, Ali A, Casalena D, Do BT, Ferreira R, Cheah JH, Soule CK, Deik A, Kunchok T, Schmidt DR, Renner S, Honeder SE, Wu M, Chan SH, Tseyang T, Stoltzfus AT, Michel SLJ, Greaves D, Hsu PP, Ng CW, Zhang CJ, Farsidjani A, Kent JR, Madariaga MLL, Gramatikov IMT, Matheson NJ, Lewis CA, Clish CB, Rees MG, Roth JA, Griner LM, Muir A, Auld DS, Vander Heiden MG. Abbott KL, et al. Cell Chem Biol. 2023 Sep 21;30(9):1156-1168.e7. doi: 10.1016/j.chembiol.2023.08.007. Epub 2023 Sep 8. Cell Chem Biol. 2023. PMID: 37689063
Ablative radiotherapy improves survival but does not cure autochthonous mouse models of prostate and colorectal cancer.
Schmidt DR, Gramatikov IMT, Sheen A, Williams CL, Hurwitz M, Dodge LE, Holupka E, Kiger WS 3rd, Cornwall-Brady MR, Huang W, Mak HH, Cormier KS, Condon C, Dane Wittrup K, Yilmaz ÖH, Stevenson MA, Down JD, Floyd SR, Roper J, Vander Heiden MG. Schmidt DR, et al. Commun Med (Lond). 2023 Aug 9;3(1):108. doi: 10.1038/s43856-023-00336-3. Commun Med (Lond). 2023. PMID: 37558833 Free PMC article.
Adipose tissue and skeletal muscle wasting precede clinical diagnosis of pancreatic cancer.
Babic A, Rosenthal MH, Sundaresan TK, Khalaf N, Lee V, Brais LK, Loftus M, Caplan L, Denning S, Gurung A, Harrod J, Schawkat K, Yuan C, Wang QL, Lee AA, Biller LH, Yurgelun MB, Ng K, Nowak JA, Aguirre AJ, Bhatia SN, Vander Heiden MG, Van Den Eeden SK, Caan BJ, Wolpin BM. Babic A, et al. Nat Commun. 2023 Jul 18;14(1):4317. doi: 10.1038/s41467-023-40024-3. Nat Commun. 2023. PMID: 37463915 Free PMC article.
A metabolic map of the DNA damage response identifies PRDX1 in the control of nuclear ROS scavenging and aspartate availability.
Moretton A, Kourtis S, Gañez Zapater A, Calabrò C, Espinar Calvo ML, Fontaine F, Darai E, Abad Cortel E, Block S, Pascual-Reguant L, Pardo-Lorente N, Ghose R, Vander Heiden MG, Janic A, Müller AC, Loizou JI, Sdelci S. Moretton A, et al. Mol Syst Biol. 2023 Jul 11;19(7):e11267. doi: 10.15252/msb.202211267. Epub 2023 Jun 1. Mol Syst Biol. 2023. PMID: 37259925 Free PMC article.
Neurons require glucose uptake and glycolysis in vivo.
Li H, Guglielmetti C, Sei YJ, Zilberter M, Le Page LM, Shields L, Yang J, Nguyen K, Tiret B, Gao X, Bennett N, Lo I, Dayton TL, Kampmann M, Huang Y, Rathmell JC, Vander Heiden M, Chaumeil MM, Nakamura K. Li H, et al. Cell Rep. 2023 Apr 25;42(4):112335. doi: 10.1016/j.celrep.2023.112335. Epub 2023 Apr 6. Cell Rep. 2023. PMID: 37027294 Free PMC article.
Histone Deacetylase 6 Inhibition Exploits Selective Metabolic Vulnerabilities in LKB1 Mutant, KRAS Driven NSCLC.
Zhang H, Nabel CS, Li D, O'Connor RÍ, Crosby CR, Chang SM, Hao Y, Stanley R, Sahu S, Levin DS, Chen T, Tang S, Huang HY, Meynardie M, Stephens J, Sherman F, Chafitz A, Costelloe N, Rodrigues DA, Fogarty H, Kiernan MG, Cronin F, Papadopoulos E, Ploszaj M, Weerasekara V, Deng J, Kiely P, Bardeesy N, Vander Heiden MG, Chonghaile TN, Dowling CM, Wong KK. Zhang H, et al. J Thorac Oncol. 2023 Jul;18(7):882-895. doi: 10.1016/j.jtho.2023.03.014. Epub 2023 Mar 22. J Thorac Oncol. 2023. PMID: 36958689 Free article.
56 results