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2019 1
2020 8
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2022 5
2023 7
2024 1

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DNA-Diffusion: Leveraging Generative Models for Controlling Chromatin Accessibility and Gene Expression via Synthetic Regulatory Elements.
DaSilva LF, Senan S, Patel ZM, Janardhan Reddy A, Gabbita S, Nussbaum Z, Valdez Córdova CM, Wenteler A, Weber N, Tunjic TM, Ahmad Khan T, Li Z, Smith C, Bejan M, Karmel Louis L, Cornejo P, Connell W, Wong ES, Meuleman W, Pinello L. DaSilva LF, et al. bioRxiv [Preprint]. 2024 Feb 1:2024.02.01.578352. doi: 10.1101/2024.02.01.578352. bioRxiv. 2024. PMID: 38352499 Free PMC article. Preprint.
Human genetic diversity alters off-target outcomes of therapeutic gene editing.
Cancellieri S, Zeng J, Lin LY, Tognon M, Nguyen MA, Lin J, Bombieri N, Maitland SA, Ciuculescu MF, Katta V, Tsai SQ, Armant M, Wolfe SA, Giugno R, Bauer DE, Pinello L. Cancellieri S, et al. Nat Genet. 2023 Jan;55(1):34-43. doi: 10.1038/s41588-022-01257-y. Epub 2022 Dec 15. Nat Genet. 2023. PMID: 36522432 Free PMC article.
Precise DNA cleavage using CRISPR-SpRYgests.
Christie KA, Guo JA, Silverstein RA, Doll RM, Mabuchi M, Stutzman HE, Lin J, Ma L, Walton RT, Pinello L, Robb GB, Kleinstiver BP. Christie KA, et al. Nat Biotechnol. 2023 Mar;41(3):409-416. doi: 10.1038/s41587-022-01492-y. Epub 2022 Oct 6. Nat Biotechnol. 2023. PMID: 36203014 Free PMC article.
Single-cell analysis and functional characterization uncover the stem cell hierarchies and developmental origins of rhabdomyosarcoma.
Wei Y, Qin Q, Yan C, Hayes MN, Garcia SP, Xi H, Do D, Jin AH, Eng TC, McCarthy KM, Adhikari A, Onozato ML, Spentzos D, Neilsen GP, Iafrate AJ, Wexler LH, Pyle AD, Suvà ML, Dela Cruz F, Pinello L, Langenau DM. Wei Y, et al. Nat Cancer. 2022 Aug;3(8):961-975. doi: 10.1038/s43018-022-00414-w. Epub 2022 Aug 18. Nat Cancer. 2022. PMID: 35982179 Free PMC article.
31 results